Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural fungicides

ABSTRACT

A pyrimidinylbenzimidazole or triazinylbenzimidazole derivative represented by the general formula (I): 
                 
 
wherein A is N or CR 3 , and R 1 , R 2 , R 3 , X, Y and n are as defined in the disclosure.

This application is a Division of application Ser. No. 09/830,578 filed on May 8, 2001 now U.S. Pat. No. 6,576,631, which was filed as International Application No. PCT/JP99/06364 filed Nov. 15, 1999.

TECHNICAL FIELD

The present invention relates to novel pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural fungicides containing said derivatives as the active ingredients.

BACKGROUND ART

As compounds related to the pyrimidinylbenzimidazole derivatives of the present invention, 4-aminopyrimidine derivatives disclosed as pharmaceuticals in U.S. Pat. No. 5,525,604 and European Patent No. 640,599 and pyrimidine derivatives disclosed as herbicides in International Publication No. WO94/17059, are mentioned, but no disclosure regarding agricultural/horticultural fungicides has been made. French Patent No. 1,476,529 discloses benzimidazolyl sulfonamide derivatives having insecticidal and fungicidal activities, but no disclosure regarding the present compounds has been made. Further, as compounds related to the triazinylbenzimidazole derivatives of the present invention, triazine derivatives disclosed in JP-A-47-36837, JP-A-49-17677 and Kogyo Kagaku Zassi (Journal of Industrial Chemistry) vol 73, No. 5, p1000 (1970) as coloring agents for textile goods, may be mentioned, but no disclosure regarding agricultural/horticultural fungicides has been made. Further, anilinopyrimidine derivatives as production intermediates therefor have not been known.

The present invention provides novel pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural fungicides containing them as the active ingredients.

The present inventors have conducted extensive studies to create novel agricultural/horticultural fungicides and as a result, found that the pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives of the present invention (hereinafter referred to as compounds of the present invention) are novel compounds which are not disclosed in any literatures and have outstanding effects as agricultural/horticultural fungicides, and the present invention has been accomplished.

DISCLOSURE OF THE INVENTION

Namely, the present invention resides in a pyrimidinylbenzimidazole or triazinylbenzimidazole derivative represented by the general formula [I]:

{wherein A is N or CR³, each of R¹ and R² which are independent of each other, is a hydrogen atom, a halogen atom, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₃-C₆) cycloalkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₃-C₆) cycloalkoxy group, a (C₁-C₄) haloalkoxy group, a cyano (C₁-C₄) alkyloxy group, a (C₁-C₄) alkoxy (C₁-C₄) alkyloxy group, a (C₃-C₆) cycloalkyl (C₁-C₄) alkoxy group, a benzyloxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₆) alkylthio group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a phenoxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₄) alkylcarbonyl group, a formyl group, a phenyl group, a di(C₁-C₄) alkylamino group, a cyano group or a (C₁-C₆) alkylsulfonyl group, R³ is a hydrogen atom, a (C₁-C₆) alkyl group, a (C₁-C₆) alkoxy group or a halogen atom, X is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₃-C₆) cycloalkyl group, a benzyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₁-C₆) alkylthio group, a (C₁-C₆) alkylsulfonyl group, a phenoxy group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₄) haloalkoxy group, a (C₁-C₄) alkylcarbonyl group, a (C₁-C₄) alkoxycarbonyl group, an amino group, a mono(C₁-C₄) alkylamino group, a di(C₁-C₄) alkylamino group, an anilino group or a phenyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], Y is a halogen atom, a nitro group, a cyano group, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₁-C₄) haloalkoxy group, a (C₁-C₆) alkylthio group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₄) alkylcarbonyl group, a (C₁-C₄) alkoxycarbonyl group, a benzoyl group, an amino group, a mono(C₁-C₄) alkylamino group, a di(C₁-C₄) alkylamino group, a phenyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group] or a phenoxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], and n is 0 or an integer of from 1 to 3}, an anilinopyrimidine or anilinotriazine derivative, as an intermediate therefor, represented by the general formula [XV]:

{wherein A is N or CR³, each of R¹ and R² which are independent of each other, is a hydrogen atom, a halogen atom, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₃-C₆) cycloalkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₃-C₆) cycloalkoxy group, a (C₁-C₄) haloalkoxy group, a cyano (C₁-C₄) alkyloxy group, a (C₁-C₄) alkoxy (C₁-C₄) alkyloxy group, a (C₃-C₆) cycloalkyl (C₁-C₄) alkoxy group, a benzyloxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₆) alkylthio group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a phenoxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₄) alkylcarbonyl group, a formyl group, a phenyl group, a di(C₁-C₄) alkylamino group, a cyano group or a (C₁-C₆) alkylsulfonyl group, R³ is a hydrogen atom, a (C₁-C₆) alkyl group, a (C₁-C₆) alkoxy group or a halogen atom, R⁵ is an amino group, a nitro group or —NHCOX, X is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₃-C₆) cycloalkyl group, a benzyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₁-C₆) alkylthio group, a (C₁-C₆) alkylsulfonyl group, a phenoxy group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₄) haloalkoxy group, a (C₁-C₄) alkylcarbonyl group, a (C₁-C₄) alkoxycarbonyl group, an amino group, a mono(C₁-C₄) alkylamino group, a di(C₁-C₄) alkylamino group, an anilino group or a phenyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], Y is a halogen atom, a nitro group, a cyano group, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₁-C₄) haloalkoxy group, a (C₁-C₆) alkylthio group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₄) alkylcarbonyl group, a (C₁-C₄) alkoxycarbonyl group, a benzoyl group, an amino group, a mono(C₁-C₄) alkylamino group, a di(C₁-C₄) alkylamino group, a phenyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group] or a phenoxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], and n is 0 or an integer of from 1 to 3}, and an agricultural/horticultural fungicide containing the pyrimidinylbenzimidazole or triazinylbenzimidazole derivative as the active ingredient.

Now, the symbols and terms used in the present specification will be explained below.

The halogen atom is a fluorine atom, a chlorine atom, a bromine atom or an iodine atom.

A notation such as (C₁-C₆) indicates that the carbon number of a substituent following this notation is from 1 to 6 in this case.

The (C₁-C₆) alkyl group is a linear or branched alkyl group and may, for example, be methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl or 3,3-dimethylbutyl.

The (C₃-C₆) cycloalkyl may, for example, be cyclopropyl, cyclopentyl or cyclohexyl.

The (C₁-C₄) haloalkyl group is a linear or branched alkyl group substituted by a halogen atom and may, for example, be fluoromethyl, chloromethyl, difluoromethyl, dichloromethyl, trifluoromethyl or pentafluoroethyl.

The (C₂-C₆) alkenyl group is a linear or branched alkenyl group and may, for example, be vinyl, 1-propenyl, 2-propenyl, isopropenyl, 1-butenyl or 2-butenyl.

The (C₂-C₆) alkynyl group is a linear or branched alkynyl group and may, for example, be ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 4-methyl-1-pentynyl or 3-methyl-1-pentynyl.

The (C₁-C₆) alkoxy group is an alkyloxy group wherein the alkyl moiety has the above meaning and may, for example, be methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, n-pentyloxy, isopentyloxy or n-hexyloxy.

The (C₂-C₆) alkenyloxy group is an alkenyloxy group wherein the alkenyl moiety has the above meaning, and may, for example, be allyloxy, isopropenyloxy or 2-butenyloxy.

The (C₂-C₆) alkynyloxy group is an alkynyloxy group wherein the alkynyl moiety has the above meaning, and may, for example, be 2-propynyloxy, 2-butynyloxy or 3-butynyloxy.

The (C₃-C₆) cycloalkoxy group is a cycloalkyloxy group wherein the cycloalkyl moiety has the above meaning, and may, for example, be cyclopropyloxy, cyclopentyloxy or cyclohexyloxy.

The (C₁-C₄) haloalkoxy group is a haloalkyloxy group wherein the haloalkyl moiety has the above meaning, and may, for example, be fluoromethoxy, difluoromethoxy, trifluoromethoxy or pentafluoroethoxy.

The (C₁-C₆) alkylthio group is an alkylthio group wherein the alkyl moiety has the above meaning, and may, for example, be methylthio, ethylthio, n-propylthio, isopropylthio, n-butylthio, isobutylthio, sec-butylthio, tert-butylthio or n-hexylthio.

The (C₃-C₆) cycloalkyl (C₁-C₄) alkoxy group may, for example, be cyclopropylmethyloxy, cyclopentylmethyloxy or cyclohexylmethyloxy.

The (C₁-C₄) alkoxy (C₁-C₄) alkyl group is a group wherein the alkyl moiety and the alkoxy moiety have the above meanings, and may, for example, be a group such as methoxymethyl, ethoxymethyl, isopropoxymethyl, pentyloxymethyl, methoxyethyl or butoxyethyl.

The (C₁-C₄) alkoxy (C₁-C₄) alkyloxy group is a group wherein the alkyl moiety and the alkoxy moiety have the above meanings, and may, for example, be a group such as methoxymethyloxy, ethoxymethyloxy, isopropoxymethyloxy, pentyloxymethyloxy, methoxyethyloxy or butoxyethyloxy.

The cyano (C₁-C₄) alkyloxy group is a group wherein the alkyl moiety has the above meaning, and may, for example, be a group such as cyanomethyloxy, cyanoethyloxy or cyanopropyloxy.

The (C₁-C₄) alkylcarbonyl group is an alkylcarbonyl group wherein the alkyl moiety has the above meaning, and may, for example, be a group such as acetyl, propionyl, butyryl, isobutyryl, pivaloyl or hexanoyl.

The (C₁-C₄) alkoxycarbonyl group is an alkoxycarbonyl group wherein the alkoxy moiety has the above meaning, and may, for example, be methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, n-pentyloxycarbonyl or n-hexyloxycarbonyl.

The mono (C₁-C₄) alkylamino group is a monoalkylamino group wherein the alkyl moiety has the above meaning, and may, for example, be methylamino, ethylamino, n-propylamino, isopropylamino, n-butylamino, isobutylamino, sec-butylamino, tert-butylamino or n-hexylamino.

The di (C₁-C₄) alkylamino group may, for example, be dimethylamino, diethylamino, dipropylamino or dibutylamino.

The (C₁-C₆) alkylsulfonyl group is an alkylsulfonyl group wherein the alkyl moiety has the above meaning, and may, for example, be methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl or n-hexylsulfonyl.

Now, specific examples of the compounds of the present invention represented by the general formula [I] will be disclosed in Tables 1 to 35. However, the compounds of the present invention are not limited to such compounds. Here, the compound numbers will be referred to in the subsequent description.

Symbols in the Tables have the following meanings respectively. Me represents methyl, Et represents ethyl, Pr represents n-propyl, Pr-i represents isopropyl, Bu represents n-butyl, Pr-c represents cyclopropyl, Pn-c represents cyclopentyl, Ph represents phenyl, and Bn represents benzyl. Further, Ph(2-Cl) represents 2-chlorophenyl, and Bn(4-Cl) represents 4-chlorobenzyl, for example.

TABLE 1

m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) I-1 H H CH OMe OMe 167-169 1-2 Cl H CH OMe OMe 90-91 1-3 Br H CH OMe OMe 87-90 1-4 SMe H CH OMe OMe 135-137 1-5 SO₂Me H CH OMe OMe 114-117 1-6 Me H CH OMe OMe 132-134 1-7 Et H CH OMe OMe 102-104 1-8 Pr H CH OMe OMe 107-110 1-9 Pr-i H CH OMe OMe 70-73 1-10 Pr-c H CH OMe OMe 62-64 1-11 Bu H CH OMe OMe 1-12 Bn H CH OMe OMe 94-96 1-13 Bn(4-Cl) H CH OMe OMe 122-125 1-14 Bn(4-Me) H CH OMe OMe 88-90 1-15 Bn(4-OMe) H CH OMe OMe 1-16 CH═CH₂ H CH OMe OMe 1-17 C≡CH H CH OMe OMe 1-18 OMe H CH OMe OMe 121-122 1-19 OCH₂CH═CH₂ H CH OMe OMe 1-20 OCH₂C≡CH H CH OMe OMe 1-21 CH₂CF₃ H CH OMe OMe 1-22 CH₂OEt H CH OMe OMe 103-104 1-23 CH₂Cl H CH OMe OMe 132-135 1-24 CH₂I H CH OMe OMe 138-141 1-25 CCl₃ H CH OMe OMe 128-131 1-26 CF₃ H CH OMe OMe 79-80 1-27 C₂F₅ H CH OMe OMe 97-100 1-28 NH₂ H CH OMe OMe m.p. Melting point RI: Refractive index

TABLE 2 m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) I-29 NHMe H CH OMe OMe 135-138 I-30 N(Me)₂ H CH OMe OMe 1.5642 I-31 NHPh H CH OMe OMe I-32 CO₂Et H CH OMe OMe I-33 COMe H CH OMe OMe I-34 Ph H CH OMe OMe 1.6219 I-35 Ph(4-Cl) H CH OMe OMe 141-144 I-36 Ph(4-Me) H CH OMe OMe I-37 Ph(4-OMe) H CH OMe OMe I-38 CN H CH OMe OMe 167-168 I-39 NO₂ H CH OMe OMe I-40 H H N OMe OMe 148-151 I-41 Cl H N OMe OMe 168-171 I-42 Br H N OMe OMe I-43 SMe H N OMe OMe I-44 SO₂Me H N OMe OMe I-45 Me H N OMe OMe 180-182 I-46 Et H N OMe OMe I-47 Pr H N OMe OMe 127-128 I-48 Pr-i H N OMe OMe 135-141 I-49 Pr-c H N OMe OMe I-50 Bu H N OMe OMe I-51 Bn H N OMe OMe I-52 Bn(4-Cl) H N OMe OMe I-53 Bn(4-Me) H N OMe OMe I-54 Bn(4-OMe) H N OMe OMe I-55 CH═CH₂ H N OMe OMe I-56 C≡CH H N OMe OMe I-57 OMe H N OMe OMe I-58 OCH₂CH═CH₂ H N OMe OMe I-59 OCH₂C≡CH H N OMe OMe I-60 OCH₂CF₃ H N OMe OMe I-61 OPh H N OMe OMe I-62 CH₂OEt H N OMe OMe

TABLE 3 m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) I-63 CH₂Cl H N OMe OMe I-64 CH₂I H N OMe OMe I-65 CCl₃ H N OMe OMe I-66 CF₃ H N OMe OMe 143-146 I-67 C₂F₂ H N OMe OMe I-68 NH₂ H N OMe OMe 261-264 I-69 NHMe H N OMe OMe I-70 N(Me)₂ H N OMe OMe I-71 NHPh H N OMe OMe I-72 CO₂Et H N OMe OMe I-73 COMe H N OMe OMe I-74 Ph H N OMe OMe I-75 Ph(4-Cl) H N OMe OMe I-76 Ph(4-Me) H N OMe OMe I-77 Ph(4-OMe) H N OMe OMe I-78 CN H N OMe OMe I-79 NO₂ H N OMe OMe I-80 H 4-Me CH OMe OMe 138-141 I-81 H 4-Cl CH OMe OMe I-82 H 5-F CH OMe OMe 175-178 I-83 H 5-Cl CH OMe OMe 181-184 I-84 H 5-Br CH OMe OMe 181-184 I-85 H 5-Me CH OMe OMe 168-169 I-86 H 5-Bu-t CH OMe OMe 138-141 I-87 H 5-CF₃ CH OMe OMe 173-174 I-88 H 5-OMe CH OMe OMe 162-164 I-89 H 5-OEt CH OMe OMe 169-171 I-90 H 5-OPr CH OMe OMe I-91 H 5-OCF₃ CH OMe OMe 138-141 I-92 H 5-OCH₂CH═CH₂ CH OMe OMe I-93 H 5-OCH₂C≡CH CH OMe OMe I-94 H 5-OPh CH OMe OMe I-95 H 5-OPh(4-Cl) CH OMe OMe I-96 H 5-OPh(4-Me) CH OMe OMe

TABLE 4 m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) I-97 H 5-OPh(4-OMe) CH OMe OMe I-98 H 5-SMe CH OMe OMe I-99 H 5-CH₂OMe CH OMe OMe I-100 H 5-COMe CH OMe OMe I-101 H 5-COPh CH OMe OMe 223-226 I-102 H 5-CO₂Et CH OMe OMe 185-188 I-103 H 5-Ph CH OMe OMe 162-165 I-104 H 5-Ph(4-Cl) CH OMe OMe I-105 H 5-Ph(4-Me) CH OMe OMe I-106 H 5-Ph(4-OMe) CH OMe OMe I-107 H 5-NO₂ CH OMe OMe I-108 H 5-NH₂ CH OMe OMe I-109 H 5-NHMe CH OMe OMe I-110 H 5-N(Me)₂ CH OMe OMe I-111 H 5-CN CH OMe OMe 249-252 I-112 H 6-F CH OMe OMe 192-193 I-113 H 6-Cl CH OMe OMe 199-202 I-114 H 6-Me CH OMe OMe 134-136 I-115 H 6-CF₃ CH OMe OMe 192-193 I-116 H 6-OMe CH OMe OMe 184-185 I-117 H 6-CO₂Et CH OMe OMe 184-187 I-118 H 6-COPh CH OMe OMe 176-179 I-119 H 7-Me CH OMe OMe 134-137 I-120 H 7-Cl CH OMe OMe I-121 H 5,6-Cl₂ CH OMe OMe 217-220 I-122 H 5,6-(Me)₂ CH OMe OMe 185-187 I-123 H 5,6-(OMe)₂ CH OMe OMe I-124 H 4-Br, 6-CF₃ CH OMe OMe 188-191 I-125 H 4-Cl, 6-CF₃ CH OMe OMe 204-206 I-126 H 4,5,6-F₃ CH OMe OMe I-127 H 4-Me N OMe OMe I-128 H 4-Cl N OMe OMe I-129 H 5-F N OMe OMe I-130 H 5-Cl N OMe OMe 175-178

TABLE 5 m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) I-131 H 5-Br N OMe OMe >300 I-132 H 5-I N OMe OMe 145-148 I-133 H 5-Me N OMe OMe 177-180 I-134 H 5-Et N OMe OMe 120-123 I-135 H 5-Pr N OMe OMe 101-104 I-136 H 5-Pr-i N OMe OMe  87-90 I-137 H 5-Bu-t N OMe OMe 146-147 I-138 H 5-CH═CH₂ N OMe OMe I-139 H 5-C≡CBu N OMe OMe I-140 H 5-CF₃ N OMe OMe I-141 H 5-OMe N OMe OMe 164-167 I-142 H 5-OEt N OMe OMe I-143 H 5-OPr N OMe OMe I-144 H 5-OCF₃ N OMe OMe I-145 H 5-OCH₂CH═CH₂ N OMe OMe I-146 H 5-OCH₂C≡CH N OMe OMe I-147 H 5-OPh N OMe OMe I-148 H 5-OPh(4-Cl) N OMe OMe I-149 H 5-OPh(4-Me) N OMe OMe I-150 H 5-OPh(4-OMe) N OMe OMe I-151 H 5-SMe N OMe OMe I-152 H 5-CH₂OMe N OMe OMe I-153 H 5-COMe N OMe OMe I-154 H 5-COPh N OMe OMe I-155 H 5-CO₂Et N OMe OMe I-156 H 5-Ph N OMe OMe I-157 H 5-Ph(4-Cl) N OMe OMe I-158 H 5-Ph(4-Me) N OMe OMe I-159 H 5-Ph(4-OMe) N OMe OMe I-160 H 5-NO₂ N OMe OMe 210-213 I-161 H 5-NH₂ N OMe OMe I-162 H 5-NHMe N OMe OMe I-163 H 5-N(Me)₂ N OMe OMe I-164 H 5-CN N OMe OMe

TABLE 6 m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) I-165 H 6-F N OMe OMe I-166 H 6-Cl N OMe OMe I-167 H 6-Me N OMe OMe I-168 H 6-CF₃ N OMe OMe I-169 H 6-OMe N OMe OMe I-170 H 6-NO₂ N OMe OMe >300 I-171 H 6-CO₂Et N OMe OMe I-172 H 6-COPh N OMe OMe I-173 H 7-Me N OMe OMe I-174 H 7-Cl N OMe OMe I-175 H 5,6-Cl₂ N OMe OMe 176-179 I-176 H 5,6-(Me)₂ N OMe OMe 193-196 I-177 H 5,6-(OMe)₂ N OMe OMe I-178 H 4-Br, 6-CF₃ N OMe OMe I-179 H 4-Cl, 6-CF₃ N OMe OMe I-180 H 4,5,6-F₃ N OMe OMe I-181 Me 4-Me CH OMe OMe 127-130 I-182 Me 4-Cl CH OMe OMe I-183 Me 5-F CH OMe OMe 163-165 I-184 Me 5-Cl CH OMe OMe 153-156 I-185 Me 5-Br CH OMe OMe 180-183 I-186 Me 5-Me CH OMe OMe 163-166 I-187 Me 5-Bu-t CH OMe OMe 126-129 I-188 Me 5-CF₃ CH OMe OMe 129-132 I-189 Me 5-OMe CH OMe OMe 190-193 I-190 Me 5-OEt CH OMe OMe 211-214 I-191 Me 5-OPr CH OMe OMe I-192 Me 5-OCF₃ CH OMe OMe 137-139 I-193 Me 5-OPh CH OMe OMe I-194 Me 5-CO₂Et CH OMe OMe 173-176 I-195 Me 5-COPh CH OMe OMe 169-171 I-196 Me 5-Ph CH OMe OMe 164-166 I-197 Me 5-NH₂ CH OMe OMe I-198 Me 5-N(Me)₂ CH OMe OMe

TABLE 7 m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) I-199 Me 5-CN CH OMe OMe 211-214 I-200 Me 6-F CH OMe OMe 162-163 I-201 Me 6-Cl CH OMe OMe 165-166 I-202 Me 6-Me CH OMe OMe 128-131 I-203 Me 6-CF₃ CH OMe OMe 162-165 I-204 Me 6-OMe CH OMe OMe 158-161 I-205 Me 6-OEt CH OMe OMe I-206 Me 6-OPr CH OMe OMe I-207 Me 6-CO₂Et CH OMe OMe 184-187 I-208 Me 6-COPh CH OMe OMe 179-182 I-209 Me 5,6-Cl₂ CH OMe OMe 204-206 I-210 Me 5,6-(Me)₂ CH OMe OMe 169-172 I-211 Me 5,6-(OMe)₂ CH OMe OMe I-212 Me 4-Me N OMe OMe 180-182 I-213 Me 4-Cl N OMe OMe I-214 Me 5-F N OMe OMe 185-188 I-215 Me 5-Cl N OMe OMe 173-176 I-216 Me 5-Br N OMe OMe >300 I-217 Me 5-I N OMe OMe 161-164 I-218 Me 5-Me N OMe OMe 192-195 I-219 Me 5-Et N OMe OMe 113-116 I-220 Me 5-Pr N OMe OMe 128-131 I-221 Me 5-Pr-i N OMe OMe 124-125 I-222 Me 5-Bu-t N OMe OMe 143-144 I-223 Me 5-CH═CH₂ N OMe OMe I-224 Me 5-C≡CBu N OMe OMe 111-114 I-225 Me 5-CF₃ N OMe OMe 167-170 I-226 Me 5-OMe N OMe OMe 161-164 I-227 Me 5-OEt N OMe OMe I-228 Me 5-OPr N OMe OMe I-229 Me 5-OCF₃ N OMe OMe 128-131 I-230 Me 5-OPh N OMe OMe I-231 Me 5-SMe N OMe OMe I-232 Me 5-CO₂Me N OMe OMe 148-151

TABLE 8 m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) I-233 Me 5-CO₂Et N OMe OMe I-234 Me 5-COMe N OMe OMe 155-158 I-235 Me 5-COPh N OMe OMe 163-166 I-236 Me 5-Ph N OMe OMe I-237 Me 5-NH₂ N OMe OMe I-238 Me 5-N(Me)₂ N OMe OMe I-239 Me 5-CN N OMe OMe 188-191 I-240 Me 6-F N OMe OMe I-241 Me 6-Cl N OMe OMe I-242 Me 6-Me N OMe OMe 130-133 I-243 Me 6-CF₃ N OMe OMe I-244 Me 6-OMe N OMe OMe I-245 Me 6-OEt N OMe OMe I-246 Me 6-OPr N OMe OMe I-247 Me 6-CO₂Et N OMe OMe I-248 Me 6-COPh N OMe OMe I-249 Me 5,6-Cl₂ N OMe OMe I-250 Me 4,6-(Me)₂ N OMe OMe 172-175 I-251 Me 5,6-(Me)₂ N OMe OMe 165-168 I-252 Me 5,6-(OMe)₂ N OMe OMe I-253 Cl 4-Me CH OMe OMe I-254 Cl 4-Cl CH OMe OMe I-255 Cl 5-F CH OMe OMe 139-142 I-256 Cl 5-Cl CH OMe OMe 159-161 I-257 Cl 5-Br CH OMe OMe I-258 Cl 5-Me CH OMe OMe 145-148 I-259 Cl 5-CF₃ CH OMe OMe 136-139 I-260 Cl 5-OMe CH OMe OMe 148-150 I-261 Cl 5-OEt CH OMe OMe 187-190 I-262 Cl 5-OPr CH OMe OMe I-263 Cl 5-OCF₃ CH OMe OMe 102-105 I-264 Cl 5-OPh CH OMe OMe I-265 Cl 5-COPh CH OMe OMe I-266 Cl 5-Ph CH OMe OMe

TABLE 9 m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) I-267 Cl 5-NH₂ CH OMe OMe I-268 Cl 5-N(Me)₂ CH OMe OMe I-269 Cl 5-CN CH OMe OMe I-270 Cl 6-F CH OMe OMe I-271 Cl 6-Cl CH OMe OMe 163-164 I-272 Cl 6-Me CH OMe OMe  98-101 I-273 Cl 5,6-(OMe)₂ CH OMe OMe I-274 Cl 4-Me N OMe OMe I-275 Cl 4-Cl N OMe OMe I-276 Cl 5-F N OMe OMe I-277 Cl 5-Cl N OMe OMe 146-149 I-278 Cl 5-Br N OMe OMe I-279 Cl 5-Me N OMe OMe 159-162 I-280 Cl 5-CF₃ N OMe OMe I-281 Cl 5-OMe N OMe OMe I-282 Cl 5-OEt N OMe OMe I-283 Cl 5-OPr N OMe OMe I-284 Cl 5-OCF₃ N OMe OMe I-285 Cl 5-OPh N OMe OMe I-286 Cl 5-COPh N OMe OMe I-287 Cl 5-Ph N OMe OMe I-288 Cl 5-NH₂ N OMe OMe I-289 Cl 5-N(Me)₂ N OMe OMe I-290 Cl 5-CN N OMe OMe I-291 Cl 6-F N OMe OMe I-292 Cl 6-Cl N OMe OMe I-293 Cl 6-Me N OMe OMe I-294 Cl 5,6-(OMe)₂ N OMe OMe I-295 CF₃ 5-F CH OMe OMe 133-136 I-296 CF₃ 5-Cl CH OMe OMe 114-116 I-297 CF₃ 5-Br CH OMe OMe I-298 CF₃ 5-Me CH OMe OMe  93-96 I-299 CF₃ 5-CF₃ CH OMe OMe  78-79 I-300 CF₃ 5-OMe CH OMe OMe 129-132

TABLE 10 m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) I-301 CF₃ 5-OEt CH OMe OMe 151-154 I-302 CF₃ 5-OPr CH OMe OMe I-303 CF₃ 5-N(Me)₂ CH OMe OMe I-304 CF₃ 5-CN CH OMe OMe I-305 CF₃ 6-F CH OMe OMe I-306 CF₃ 6-Cl CH OMe OMe I-307 CF₃ 6-Me CH OMe OMe 132-135 I-308 CF₃ 5,6-(OMe)₂ CH OMe OMe I-309 CF₃ 5-F N OMe OMe 170-173 I-310 CF₃ 5-Cl N OMe OMe 135-138 I-311 CF₃ 5-Br N OMe OMe 111-114 I-312 CF₃ 5-Me N OMe OMe 137-140 I-313 CF₃ 5-Et N OMe OMe 104-107 I-314 CF₃ 5-Pr N OMe OMe  89-92 I-315 CF₃ 5-Pr-i N OMe OMe 118-121 I-316 CF₃ 5-Bu-t N OMe OMe 113-116 I-317 CF₃ 5-CF₃ N OMe OMe I-318 CF₃ 5-OMe N OMe OMe 165-168 I-319 CF₃ 5-OEt N OMe OMe I-320 CF₃ 5-OPr N OMe OMe I-321 CF₃ 5-OCF₃ N OMe OMe 187-190 I-322 CF₃ 5-SMe N OMe OMe I-323 CF₃ 5-NHMe N OMe OMe I-324 CF₃ 5-N(Me)₂ N OMe OMe I-325 CF₃ 5-CN N OMe OMe 188-191 I-326 CF₃ 5-CO₂Me N OMe OMe 126-129 I-327 CF₃ 5-I N OMe OMe 115-118 I-328 CF₃ 6-F N OMe OMe I-329 CF₃ 6-Cl N OMe OMe I-330 CF₃ 6-Me N OMe OMe I-331 CF₃ 5,6-(OMe)₂ N OMe OMe I-332 Et 5-F CH OMe OMe 135-138 I-333 Et 5-Cl CH OMe OMe 137-140 I-334 Et 5-Me CH OMe OMe 120-122

TABLE 11 m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) I-335 Et 5-CF₃ CH OMe OMe 117-118 I-336 Et 5-OMe CH OMe OMe 118-120 I-337 Et 5-OEt CH OMe OMe I-338 Et 5-OPr CH OMe OMe I-339 Et 5-N(Me)₂ CH OMe OMe I-340 Et 5-CN CH OMe OMe I-341 Et 6-F CH OMe OMe I-342 Et 6-Cl CH OMe OMe I-343 Et 6-Me CH OMe OMe I-344 Et 5,6-(OMe)₂ CH OMe OMe I-345 Et 5-F N OMe OMe I-346 Et 5-Cl N OMe OMe 125-128 I-347 Et 5-Me N OMe OMe I-348 Et 5-CF₃ N OMe OMe I-349 Et 5-OMe N OMe OMe I-350 Et 5-OEt N OMe OMe I-351 Et 5-OPr N OMe OMe I-352 Et 5-N(Me)₂ N OMe OMe I-353 Et 5-CN N OMe OMe I-354 Et 6-F N OMe OMe I-355 Et 6-Cl N OMe OMe I-356 Et 6-Me N OMe OMe I-357 Et 5,6-(OMe)₂ N OMe OMe I-358 Pr 5-Cl N OMe OMe 128-131 I-359 Pr-i 5-Cl N OMe OMe 160-163 I-360 Pr-c 5-Cl N OMe OMe 146-149 I-361 NH₂ 5-F CH OMe OMe 236-239 I-362 NH₂ 5-Me CH OMe OMe >300 I-363 NH₂ 5-CF₃ CH OMe OMe 268-271 I-364 NH₂ 5-OMe CH OMe OMe 232-235 I-365 NH₂ 5-OEt CH OMe OMe 239-242 I-366 NH₂ 6-Me CH OMe OMe >300 I-367 NH₂ 5,6-(OMe)₂ CH OMe OMe I-368 NH₂ 5-Cl N OMe OMe 293-296

TABLE 12 m.p. (° C.) Com- or pound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-369 NH₂ 5-Me N OMe OMe 272-275 I-370 NH₂ 5-CF₃ N OMe OMe I-371 NH₂ 5-OMe N OMe OMe I-372 NH₂ 5-OEt N OMe OMe I-373 NH₂ 6-Me N OMe OMe I-374 NH₂ 5,6-(OMe)₂ N OMe OMe I-375 NHMe 5-Cl N OMe OMe 238-241 I-376 N(Me)₂ 5-Cl N OMe OMe 66-69 I-377 CH₂OMe 5-Cl N OMe OMe 105-108 I-378 Ph 5-Cl N OMe OMe 137-140 I-379 Bn 5-Cl N OMe OMe 192-195 I-380 CN 5-Cl CH OMe OMe 223-226 I-381 CN 5-Me CH OMe OMe 229-231 I-382 CN 5-CF₃ CH OMe OMe I-383 CN 5-OMe CH OMe OMe I-384 CN 5-Cl N OMe OMe I-385 CN 5-Me N OMe OMe I-386 CN 5-CF₃ N OMe OMe I-387 CN 5-OMe N OMe OMe I-388 SMe 5-Cl CH OMe OMe 184-187 I-389 SMe 5-Me CH OMe OMe 155-158 I-390 SMe 5-CF₃ CH OMe OMe I-391 SMe 5-OMe CH OMe OMe I-392 SMe 6-Cl CH OMe OMe I-393 SMe 6-Me CH OMe OMe I-394 SMe 5-Cl N OMe OMe 135-138 I-395 SMe 5-Me N OMe OMe I-396 SMe 5-CF₃ N OMe OMe I-397 SMe 5-OMe N OMe OMe I-398 SMe 6-Cl N OMe OMe I-399 SMe 6-Me N OMe OMe I-400 CCl₃ 5-Cl CH OMe OMe 132-134 I-401 CCl₃ 5-Me CH OMe OMe I-402 CCl₃ 5-OMe CH OMe OMe

TABLE 13 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-403 CCl₃ 6-Cl CH OMe OMe I-404 CCl₃ 6-Me CH OMe OMe 136-139 I-405 CCL₃ 5-Cl N OMe OMe 123-126 I-406 CCl₃ 5-Me N OMe OMe 140-151 I-407 CCl₃ 5-OMe N OMe OMe I-408 CCl₃ 5-Br N OMe OMe I-409 CCl₃ 6-Cl N OMe OMe I-410 CCl₃ 6-Me N OMe OMe I-411 CF₂Cl 5-Me N OMe OMe 109-111 I-412 CF₂Cl 5-Cl N OMe OMe 86-89 I-413 CF₂Cl 5-Br N OMe OMe I-414 CF₂Cl 5-OMe N OMe OMe I-415 CH₂Cl 5-Me N OMe OMe 143-145 I-416 CH₂Cl 5-Cl N OMe OMe 160-161 I-417 CH₂Cl 5-Br N OMe OMe I-418 CH₂Cl 5-OMe N OMe OMe I-419 C₂F₅ 5-Me N OMe OMe I-420 C₂F₅ 5-Cl N OMe OMe I-421 C₂F₅ 5-Br N OMe OMe I-422 C₂F₅ 5-OMe N OMe OMe I-423 SO₂Me 5-Cl CH OMe OMe 149-152 I-424 SO₂Me 5-Me CH OMe OMe 176-177 I-425 SO₂Me 6-Me CH OMe OMe I-426 SO₂Me 5-Cl N OMe OMe I-427 SO₂Me 5-Me N OMe OMe I-428 SO₂Me 6-Me N OMe OMe I-429 OMe 5-Cl CH OMe OMe 182-185 I-430 OMe 6-Cl CH OMe OMe 178-180 I-431 OMe 5-Cl N OMe OMe I-432 OMe 6-Cl N OMe OMe I-433 H H N OMe OEt I-434 H 5-Cl N OMe OEt I-435 H 5-Br N OMe OEt 194-196 I-436 H 5-Me N OMe OEt

TABLE 14 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-437 Me H N OMe OEt I-438 Me 5-Cl N OMe OEt 153-156 I-439 Me 5-Br N OMe OEt 143-145 I-440 Me 5-Me N OMe OEt 155-156 I-441 Cl 5-Cl N OMe OEt I-442 Cl 5-Br N OMe OEt I-443 Cl 5-Me N OMe OEt I-444 CF₃ H N OMe OEt I-445 CF₃ 5-Me N OMe OEt 147-150 I-446 CF₃ 5-Cl N OMe OEt 149-151 I-447 CF₃ 5-Br N OMe OEt 138-139 I-448 CF₂Cl 5-Cl N OMe OEt I-449 CF₂Cl 5-Br N OMe OEt I-450 CF₂Cl 5-Me N OMe OEt I-451 CH₂Cl 5-Cl N OMe OEt I-452 CH₂Cl 5-Br N OMe OEt I-453 CH₂Cl 5-Me N OMe OEt I-454 C₂F₅ 5-Cl N OMe OEt I-455 C₂F₅ 5-Br N OMe OEt I-456 C₂F₅ 5-Me N OMe OEt I-457 H H CH OEt OEt 122-124 I-458 Cl H CH OEt OEt 79-82 I-459 Br H CH OEt OEt I-460 SMe H CH OEt OEt 122-125 I-461 Me H CH OEt OEt 88-91 I-462 Et H CH OEt OEt 90-93 I-463 OMe H CH OEt OEt 87-89 I-464 OEt H CH OEt OEt 96-99 I-465 CF₃ H CH OEt OEt 90-92 I-466 NH₂ H CH OEt OEt 222-225 I-467 CN H CH OEt OEt 153-156 I-468 H H N OEt OEt I-469 Cl H N OEt OEt I-470 Br H N OEt OEt

TABLE 15 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-471 SMe H N OEt OEt I-472 Me H N OEt OEt I-473 Et H N OEt OEt I-474 OMe H N OEt OEt I-475 OEt H N OEt OEt I-476 CF₃ H N OEt OEt I-477 NH₂ H N OEt OEt I-478 CN H N OEt OEt I-479 H 5-F CH OEt OEt 156-159 I-480 H 5-Cl CH OEt OEt 177-180 I-481 H 5-Br CH OEt OEt I-482 H 5-Me CH OEt OEt 135-138 I-483 H 5-CF₃ CH OEt OEt 165-168 I-484 H 5-OMe CH OEt OEt I-485 H 5-OEt CH OEt OEt I-486 H 6-Cl CH OEt OEt 164-167 I-487 H 5,6-(OMe)₂ CH OEt OEt I-488 H 5-F N OEt OEt I-489 H 5-Cl N OEt OEt I-490 H 5-Br N OEt OEt 170-173 I-491 H 5-Me N OEt OEt I-492 H 5-Bu-t N OEt OEt 107-110 I-493 H 5-CF₃ N OEt OEt I-494 H 5-OMe N OEt OEt I-495 H 5-OEt N OEt OEt I-496 H 6-Cl N OEt OEt I-497 H 5,6-(OMe)₂ N OEt OEt I-498 Me 5-F CH OEt OEt 131-133 I-499 Me 5-Cl CH OEt OEt 171-174 I-500 Me 5-Br CH OEt OEt I-501 Me 5-Me CH OEt OEt 119-122 I-502 Me 5-CF₃ CH OEt OEt 131-134 I-503 Me 5-OMe CH OEt OEt 141-144 I-504 Me 5-OEt CH OEt OEt

TABLE 16 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-505 Me 5-OCF₃ CH OEt OEt I-506 Me 5-CN CH OEt OEt I-507 Me 6-F CH OEt OEt 133-134 I-508 Me 6-Cl CH OEt OEt 146-149 I-509 Me 6-Me CH OEt OEt I-510 Me 6-CF₃ CH OEt OEt 138-141 I-511 Me 6-OMe CH OEt OEt 135-138 I-512 Me 5,6-(OMe)₂ CH OEt OEt I-513 Me 5-F N OEt OEt I-514 Me 5-Cl N OEt OEt 175-178 I-515 Me 5-Br N OEt OEt 169-172 I-516 Me 5-Me N OEt OEt 141-144 I-517 Me 5-Bu-t N OEt OEt 107-109 I-518 Me 5-CF₃ N OEt OEt I-519 Me 5-OMe N OEt OEt I-520 Me 5-OEt N OEt OEt I-521 Me 5-OCF₃ N OEt OEt I-522 Me 5-CN N OEt OEt I-523 Me 6-F N OEt OEt I-524 Me 6-Cl N OEt OEt I-525 Me 6-Me N OEt OEt I-526 Me 6-CF₃ N OEt OEt I-527 Me 6-OMe N OEt OEt I-528 Me 5,6-(OMe)₂ N OEt OEt I-529 Cl 5-Cl CH OEt OEt I-530 Cl 5-Me CH OEt OEt 101-103 I-531 Cl 5-OMe CH OEt OEt 153-156 I-532 Cl 5-OEt CH OEt OEt I-533 Cl 5,6-(OMe)₂ CH OEt OEt I-534 Cl 5-Cl N OEt OEt 130-133 I-535 Cl 5-Me N OEt OEt I-536 Cl 5-OMe N OEt OEt I-537 Cl 5-OEt N OEt OEt I-538 Cl 5,6-(OMe)₂ N OEt OEt

TABLE 17 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-539 CF₃ 5-Me CH OEt OEt I-540 CF₃ 5-OMe CH OEt OEt I-541 CF₃ 5,6-(OMe)₂ CH OEt OEt I-542 CF₃ H N OEt OEt I-543 CF₃ 5-Me N OEt OEt 163-165 I-544 CF₃ 5-OMe N OEt OEt 140-143 I-545 CF₃ 5-Cl N OEt OEt 138-141 I-546 CF₃ 5-Br N OEt OEt 120-123 I-547 Et 5-Me CH OEt OEt I-548 Et 5-OMe CH OEt OEt I-549 Et 5,6-(OMe)₂ CH OEt OEt I-550 CCl₃ 5-Cl N OEt OEt 110-113 I-551 CCl₃ 5-Br N OEt OEt I-552 CCl₃ 5-Me N OEt OEt I-553 CCl₃ 5-OMe N OEt OEt I-554 CF₂Cl 5-Cl N OEt OEt I-555 CF₂Cl 5-Br N OEt OEt I-556 CF₂Cl 5-Me N OEt OEt I-557 CH₂Cl 5-Cl N OEt OEt I-558 CH₂Cl 5-Br N OEt OEt I-559 CH₂Cl 5-Me N OEt OEt I-560 C₂F₅ 5-Cl N OEt OEt I-561 C₂F₅ 5-Br N OEt OEt I-562 C₂F₅ 5-Me N OEt OEt I-563 CN 5-Cl CH OEt OEt 170-172 I-564 CN 5-OMe CH OEt OEt I-565 CN 5,6-(OMe)₂ CH OEt OEt I-566 CN 5-Me N OEt OEt I-567 CN 5-OMe N OEt OEt I-568 CN 5-Cl N OEt OEt I-569 SMe 5-Cl CH OEt OEt 167-169 I-570 SMe 5-Me CH OEt OEt I-571 SMe 5-Cl N OEt OEt I-572 SMe 5-Me N OEt OEt

TABLE 18 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-573 SO₂Me 5-Cl CH OEt OEt 167-170 I-574 SO₂Me 5-Me CH OEt OEt I-575 OMe 5-Cl CH OEt OEt 143-146 I-576 H H CH OPr OPr 89-90 I-577 H H N OPr OPr I-578 H 5-Cl N OPr OPr I-579 H 5-Br N OPr OPr I-580 Me 5-Cl N OPr OPr 128-131 I-581 Me 5-Br N OPr OPr I-582 Me 5-Me N OPr OPr I-583 CF₃ 5-Cl N OPr OPr 71-74 I-584 CF₃ 5-Br N OPr OPr I-585 CF₃ 5-Me N OPr OPr I-586 H H CH OPr-i OPr-i 115-117 I-587 Me 5-Cl CH OPr-i OPr-i I-588 Me 5-Me CH OPr-i OPr-i I-589 H H N OPr-i OPr-i I-590 H 5-Cl N OPr-i OPr-i I-591 H 5-Br N OPr-i OPr-i I-592 Me 5-Cl N OPr-i OPr-i 85-88 I-593 Me 5-Br N OPr-i OPr-i I-594 Me 5-Me N OPr-i OPr-i I-595 CF₃ 5-Cl N OPr-i OPr-i  97-100 I-596 CF₃ 5-Br N OPr-i OPr-i I-597 CF₃ 5-Me N OPr-i OPr-i I-598 H H N OCH₂CH═CH₂ OCH₂CH═CH₂ I-599 H 5-Cl N OCH₂CH═CH₂ OCH₂CH═CH₂ I-600 H 5-Br N OCH₂CH═CH₂ OCH₂CH═CH₂ I-601 Me 5-Cl N OCH₂CH═CH₂ OCH₂CH═CH₂ 158-161 I-602 Me 5-Br N OCH₂CH═CH₂ OCH₂CH═CH₂ I-603 Me 5-Me N OCH₂CH═CH₂ OCH₂CH═CH₂ I-604 CF₃ 5-Cl N OCH₂CH═CH₂ OCH₂CH═CH₂ I-605 CF₃ 5-Br N OCH₂CH═CH₂ OCH₂CH═CH₂ I-606 CF₃ 5-Me N OCH₂CH═CH₂ OCH₂CH═CH₂

TABLE 19 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-607 H H N OCH₂C≡CH OCH₂C≡CH I-608 H 5-Cl N OCH₂C≡CH OCH₂C≡CH I-609 H 5-Br N OCH₂C≡CH OCH₂C≡CH I-610 Me 5-Cl N OCH₂C≡CH OCH₂C≡CH I-611 Me 5-Br N OCH₂C≡CH OCH₂C≡CH I-612 Me 5-Me N OCH₂C≡CH OCH₂C≡CH I-613 CF₃ 5-Cl N OCH₂C≡CH OCH₂C≡CH I-614 CF₃ 5-Br N OCH₂C≡CH OCH₂C≡CH I-615 CF₃ 5-Me N OCH₂C≡CH OCH₂C≡CH I-616 Me 5-Cl CH OCH₂CN OCH₂CN I-617 Me 5-Me CH OCH₂CN OCH₂CN I-618 H 5-Br N OCH₂CN OCH₂CN I-619 Me 5-Cl N OCH₂CN OCH₂CN I-620 Me 5-Br N OCH₂CN OCH₂CN I-621 Me 5-Me N OCH₂CN OCH₂CN I-622 CF₃ 5-Cl N OCH₂CN OCH₂CN I-623 CF₃ 5-Br N OCH₂CN OCH₂CN I-624 CF₃ 5-Me N OCH₂CN OCH₂CN I-625 Me 5-Cl CH OCH₂CH₂OMe OCH₂CH₂OMe I-626 Me 5-Me CH OCH₂CH₂OMe OCH₂CH₂OMe I-627 H 5-Br N OCH₂CH₂OMe OCH₂CH₂OMe I-628 Me 5-Cl N OCH₂CH₂OMe OCH₂CH₂OMe I-629 Me 5-Br N OCH₂CH₂OMe OCH₂CH₂OMe I-630 Me 5-Me N OCH₂CH₂OMe OCH₂CH₂OMe I-631 CF₃ 5-Cl N OCH₂CH₂OMe OCH₂CH₂OMe I-632 CF₃ 5-Br N OCH₂CH₂OMe OCH₂CH₂OMe I-633 CF₃ 5-Me N OCH₂CH₂OMe OCH₂CH₂OMe I-634 H 5-Br N OCH₂Pr-c OCH₂Pr-c I-635 Me 5-Cl N OCH₂Pr-c OCH₂Pr-c I-636 Me 5-Br N OCH₂Pr-c OCH₂Pr-c I-637 Me 5-Me N OCH₂Pr-c OCH₂Pr-c I-638 CF₃ 5-Cl N OCH₂Pr-c OCH₂Pr-c I-639 CF₃ 5-Br N OCH₂Pr-c OCH₂Pr-c I-640 CF₃ 5-Me N OCH₂Pr-c OCH₂Pr-c

TABLE 20 m.p. Com- (° C.) or pound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-641 Me 5-Me CH OCH₂CH₂Cl OCH₂CH₂Cl I-642 Me 5-Cl CH OCH₂CH₂Cl OCH₂CH₂Cl I-643 Me 5-Me N OCH₂CH₂Cl OCH₂CH₂Cl I-644 Me 5-Cl N OCH₂CH₂Cl OCH₂CH₂Cl I-645 CF₃ 5-Me N OCH₂CH₂Cl OCH₂CH₂Cl I-646 CF₃ 5-Cl N OCH₂CH₂Cl OCH₂CH₂Cl I-647 Me 5-Cl N OCH₂CH₂F OCH₂CH₂F I-648 Me 5-Me N OCH₂CH₂F OCH₂CH₂F I-649 CF₃ 5-Me N OCH₂CH₂F OCH₂CH₂F 1-650 CF₃ 5-Cl N OCH₂CH₂F OCH₂CH₂F I-651 Me 5-Cl N OCH₂CF₃ OCH₂CF₃ I-652 Me 5-Me N OCH₂CF₃ OCH₂CF₃ I-653 CF₃ 5-Me N OCH₂CF₃ OCH₂CF₃ I-654 CF₃ 5-Cl N OCH₂CF₃ OCH₂CF₃ I-655 H H CH OBn OBn I-656 H H N OBn OBn I-657 H H N OBn(4-Cl) OBn(4-Cl) I-658 H H N OBn(4-Me) OBn(4-Me) I-659 H H N OBn(4-OMe) OBn(4-OMe) I-660 H H CH OMe OPh 131-132 I-661 H H N OMe OPh I-662 H H N OMe OPh(4-Cl) I-663 H H N OMe OPh(4-Me) I-664 H H N OMe OPh(4-OMe) I-665 H H CH OMe OCHF₂ 138-139 I-666 H H N OMe OCHF₂ I-667 H H CH OMe H 114-116 I-668 Me H CH OMe H I-669 H 5-Cl CH OMe H 173-176 I-670 H 5-Me CH OMe H 140-142 I-671 Me 5-Cl CH OMe H 127-130 I-672 Me 5-Me CH OMe H 113-114 I-673 Me 5- CH OMe H CF₃ I-674 Me 5- CH OMe H OMe

TABLE 21 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-675 Me 6-Cl CH OMe H 126-130 I-676 Me 5,6-(OMe)₂ CH OMe H I-677 Cl 5-Cl CH OMe H I-678 Cl 5-Me CH OMe H I-679 Cl 5-CF₃ CH OMe H I-680 Cl 5-OMe CH OMe H I-681 Cl 5,6-(OMe)₂ CH OMe H I-682 CF₃ 5-Cl CH OMe H 107-108 I-683 CF₃ 5-Me CH OMe H 76-79 I-684 CF₃ 5-CF₃ CH OMe H I-685 CF₃ 5-OMe CH OMe H I-686 Et 5-Cl CH OMe H I-687 Et 5-Me CH OMe H I-688 Et 5-CF₃ CH OMe H I-689 Et 5-OMe CH OMe H I-690 H H CH OEt H 104-107 I-691 Me H CH OEt H I-692 H 5-Cl CH OEt H 158-160 I-693 H 5-Me CH OEt H 131-132 I-694 Me 5-Cl CH OEt H 153-155 I-695 Me 5-Me CH OEt H 109-111 I-696 Me 5-CF₃ CH OEt H I-697 Me 5-OMe CH OEt H I-698 Me 5,6-(OMe)₂ CH OEt H I-699 Me 6-Cl CH OEt H 117-118 I-700 Cl 5-Me CH OEt H I-701 Cl 5-CF₃ CH OEt H I-702 Cl 5-OMe CH OEt H I-703 Cl 5,6-(OMe)₂ CH OEt H I-704 CF₃ 5-Cl CH OEt H 125-128 I-705 CF₃ 5-Me CH OEt H 86-87 I-706 CF₃ 5-OMe CH OEt H I-707 Et 5-Cl CH OEt H I-708 Et 5-Me CH OEt H

TABLE 22 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-709 Et 5-CF₃ CH OEt H I-710 Et 5-OMe CH OEt H I-711 H H CH OPr H 83-86 I-712 Me 5-Me CH OPr H I-713 Me 5-Cl CH OPr H I-714 Me 5-OMe CH OPr H I-715 H H CH OCH₂CH═CH₂ H I-716 Me 5-Me CH OCH₂CH═CH₂ H I-717 Me 5-Cl CH OCH₂CH═CH₂ H I-718 Me 5-OMe CH OCH₂CH═CH₂ H I-719 H H CH OBn H I-720 Me 5-Me CH OBn H I-721 Me 5-Cl CH OBn H I-722 H H CH OPh H 257-260 I-723 H H CH OPh(4-Cl) H I-724 H H CH OPh(4-Me) H I-725 H H CH OPh(4-OMe) H I-726 H H CH OMe Me 107-110 I-727 Me H CH OMe Me I-728 H 5-Cl CH OMe Me I-729 H 5-Me CH OMe Me I-730 H 5-CF₃ CH OMe Me I-731 Me 5-Cl CH OMe Me 124-127 I-732 Me 5-Me CH OMe Me I-733 Me 5-CF₃ CH OMe Me I-734 Me 5-OMe CH OMe Me I-735 Me 6-Cl CH OMe Me I-736 Me 5,6-(OMe)₂ CH OMe Me I-737 Cl 5-Cl CH OMe Me I-738 Cl 5-Me CH OMe Me I-739 Cl 5-OMe CH OMe Me I-740 Cl 5,6-(OMe)₂ CH OMe Me I-741 CF₃ 5-Cl CH OMe Me I-742 CF₃ 5-Me CH OMe Me

TABLE 23 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-743 CF₃ 5-OMe CH OMe Me I-744 Et 5-Cl CH OMe Me I-745 Et 5-Me CH OMe Me I-746 Et 5-OMe CH OMe Me I-747 H H N OMe Me I-748 H 5-Cl N OMe Me I-749 H 5-Me N OMe Me I-750 H 5-CF₃ N OMe Me I-751 Me 5-Cl N OMe Me I-752 Me 5-Me N OMe Me 124-127 I-753 Me 5-CF₃ N OMe Me I-754 Me 5-OMe N OMe Me I-755 Me 6-Cl N OMe Me I-756 Me 5,6-(OMe)₂ N OMe Me I-757 Cl 5-Cl N OMe Me I-758 Cl 5-Me N OMe Me 117-120 I-759 Cl 5-OMe N OMe Me I-760 Cl 5,6-(OMe)₂ N OMe Me I-761 CF₃ 5-Cl N OMe Me I-762 CF₃ 5-Me N OMe Me 117-120 I-763 CF₃ 5-OMe N OMe Me I-764 Et 5-Cl N OMe Me I-765 Et 5-Me N OMe Me I-766 Et 5-OMe N OMe Me I-767 NH₂ 5-Me N OMe Me >300 I-768 H H CH OEt Me 57-60 I-769 Me H CH OEt Me 92-94 I-770 CF₃ H CH OEt Me I-771 Cl H CH OEt Me 95-96 I-772 H 5-Me CH OEt Me 105-108 I-773 Me 5-F CH OEt Me I-774 Me 5-Cl CH OEt Me I-775 Me 5-Me CH OEt Me 108-110 I-776 Me 5-CF₃ CH OEt Me

TABLE 24 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-777 Me 5-OMe CH OEt Me I-778 Me 5-CN CH OEt Me I-779 Me 6-Cl CH OEt Me I-780 Me 5,6-(OMe)₂ CH OEt Me I-781 Cl 5-Cl CH OEt Me I-782 Cl 5-Me CH OEt Me I-783 Cl 5-CF₃ CH OEt Me I-784 Cl 5-OMe CH OEt Me I-785 Cl 5,6-(OMe)₂ CH OEt Me I-786 CF₃ 5-Cl CH OEt Me I-787 CF₃ 5-Me CH OEt Me 117-118 I-788 CF₃ 5-OMe CH OEt Me I-789 Et 5-Cl CH OEt Me I-790 Et 5-Me CH OEt Me I-791 Et 5-CF₃ CH OEt Me I-792 Et 5-OMe CH OEt Me I-793 H H N OEt Me I-794 H 5-Br N OEt Me I-795 Me 5-Cl N OEt Me I-796 Me 5-Br N OEt Me I-797 Me 5-Me N OEt Me I-798 Me 5-CF₃ N OEt Me I-799 Cl 5-Cl N OEt Me I-800 Cl 5-Me N OEt Me I-801 CF₃ 5-Cl N OEt Me I-802 CF₃ 5-Br N OEt Me I-803 CF₃ 5-Me N OEt Me I-804 H H CH OPr Me 47-50 I-805 H 5-OMe CH OPr Me 100-102 I-806 Me H CH OPr Me 75-78 I-807 CF₃ H CH OPr Me I-808 H 5-Cl CH OPr Me I-809 H 5-Me CH OPr Me 73-76 I-810 Me 5-F CH OPr Me

TABLE 25 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-811 Me 5-Cl CH OPr Me 90-93 I-812 Me 5-Me CH OPr Me 59-62 I-813 Me 5-OMe CH OPr Me  99-101 I-814 Me 6-Cl CH OPr Me 109-112 I-815 Me 5,6-(OMe)₂ CH OPr Me I-816 Cl 5-Cl CH OPr Me I-817 Cl 5-Me CH OPr Me 76-77 I-818 Cl 5-OMe CH OPr Me 87-90 I-819 Cl 5,6-(OMe)₂ CH OPr Me I-820 CF₃ 5-Cl CH OPr Me I-821 CF₃ 5-Me CH OPr Me I-822 CF₃ 5-CF₃ CH OPr Me I-823 CF₃ 5-OMe CH OPr Me I-824 Et 5-Cl CH OPr Me I-825 Et 5-Me CH OPr Me I-826 Et 5-OMe CH OPr Me I-827 H H N OPr Me I-828 H 5-Br N OPr Me I-829 Me 5-Cl N OPr Me I-830 Me 5-Br N OPr Me I-831 Me 5-Me N OPr Me 104-107 I-832 Me 5-CF₃ N OPr Me I-833 Cl 5-Cl N OPr Me I-834 Cl 5-Me N OPr Me I-835 CF₃ 5-Cl N OPr Me I-836 CF₃ 5-Br N OPr Me I-837 CF₃ 5-Me N OPr Me I-838 NH₂ 5-Me N OPr Me 152-153 I-839 H H CH OPr-i Me 66-68 I-840 Me H CH OPr-i Me 1.5805 I-841 CF₃ H CH OPr-i Me I-842 H 5-Cl CH OPr-i Me I-843 H 5-Me CH OPr-i Me I-844 Me 5-F CH OPr-i Me

TABLE 26 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-845 Me 5-Cl CH OPr-i Me I-846 Me 5-Me CH OPr-i Me I-847 Me 5-OMe CH OPr-i Me I-848 Me 6-Cl CH OPr-i Me I-849 Me 5,6-(OMe)₂ CH OPr-i Me I-850 Cl 5-Cl CH OPr-i Me I-851 Cl 5-Me CH OPr-i Me I-852 Cl 5-CF₃ CH OPr-i Me I-853 Cl 5-OMe CH OPr-i Me I-854 Cl 5,6-(OMe)₂ CH OPr-i Me I-855 CF₃ 5-Cl CH OPr-i Me I-856 CF₃ 5-Me CH OPr-i Me I-857 CF₃ 5-OMe CH OPr-i Me I-858 Et 5-Cl CH OPr-i Me I-859 Et 5-Me CH OPr-i Me I-860 Et 5-OMe CH OPr-i Me I-861 H H N OPr-i Me I-862 H 5-Br N OPr-i Me I-863 Me 5-Cl N OPr-i Me I-864 Me 5-Br N OPr-i Me I-865 Me 5-Me N OPr-i Me I-866 Me 5-CF₃ N OPr-i Me I-867 Cl 5-Cl N OPr-i Me I-868 Cl 5-Me N OPr-i Me I-869 CF₃ 5-Cl N OPr-i Me I-870 CF₃ 5-Br N OPr-i Me I-871 CF₃ 5-Me N OPr-i Me I-872 H H CH OBu Me 1.5795 I-873 Me H CH OBu Me 73-76 I-874 Me 5-Cl CH OBu Me I-875 Me 5-Me CH OBu Me I-876 Me 5-OMe CH OBu Me I-877 Cl 5-Cl CH OBu Me I-878 Cl 5-Me CH OBu Me

TABLE 27 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-879 Cl 5-OMe CH OBu Me I-880 CF₃ 5-Cl CH OBu Me I-881 CF₃ 5-Me CH OBu Me I-882 CF₃ 5-OMe CH OBu Me I-883 H H CH OCH₂CH═CH₂ Me 55-58 I-884 H 5-Me CH OCH₂CH═CH₂ Me I-885 Me H CH OCH₂CH═CH₂ Me 84-87 I-886 Me 5-Cl CH OCH₂CH═CH₂ Me I-887 Me 5-Me CH OCH₂CH═CH₂ Me I-888 Me 5-OMe CH OCH₂CH═CH₂ Me I-889 Cl 5-Cl CH OCH₂CH═CH₂ Me I-890 Cl 5-Me CH OCH₂CH═CH₂ Me I-891 CF₃ 5-Cl CH OCH₂CH═CH₂ Me I-892 CF₃ 5-Me CH OCH₂CH═CH₂ Me I-893 CF₃ 5-OMe CH OCH₂CH═CH₂ Me I-894 H H CH OCH₂C≡CH Me 145-148 I-895 H 5-Me CH OCH₂C≡CH Me 183-186 I-896 Me H CH OCH₂C≡CH Me 147-149 I-897 Me 5-Cl CH OCH₂C≡CH Me I-898 Me 5-Me CH OCH₂C≡CH Me 147-150 I-899 Me 5-OMe CH OCH₂C≡CH Me I-900 Cl 5-Cl CH OCH₂C≡CH Me I-901 Cl 5-Me CH OCH₂C≡CH Me I-902 CF₃ 5-Cl CH OCH₂C≡CH Me I-903 CF₃ 5-Me CH OCH₂C≡CH Me 113-116 I-904 NH₂ 5-Me CH OCH₂C≡CH Me 225-228 I-905 H H CH OBn Me I-906 H H CH OPn-c Me 1.5965 I-907 Me H CH OPn-c Me 1.5941 I-908 Me 5-Cl CH OPn-c Me I-909 Me 5-Cl N OPn-c Me I-910 H H CH SMe Me I-911 Me H CH SMe Me 139-142 I-912 Me 5-Me CH SMe Me

TABLE 28 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-913 Me 5-Cl CH SMe Me I-914 H H N SMe Me I-915 Me 5-Me N SMe Me 134-137 I-916 Me 5-Cl N SMe Me I-917 H H CH OMe Et I-918 Me 5-Me CH OMe Et I-919 Me 5-Cl CH OMe Et I-920 Me 5-CF₃ CH OMe Et I-921 Me 5-OMe CH OMe Et I-922 Cl 5-Me CH OMe Et I-923 Cl 5-Cl CH OMe Et I-924 H H CH OEt Et I-925 Me 5-Me CH OEt Et I-926 Me 5-Cl CH OEt Et I-927 Me 5-CF₃ CH OEt Et I-928 Me 5-OMe CH OEt Et I-929 Cl 5-Me CH OEt Et I-930 Cl 5-Cl CH OEt Et I-931 H H CH OPr Et I-932 Me 5-Me CH OPr Et I-933 Me 5-Cl CH OPr Et I-934 Me 5-CF₃ CH OPr Et I-935 Me 5-OMe CH OPr Et I-936 Cl 5-Me CH OPr Et I-937 Cl 5-Cl CH OPr Et I-938 H H N OMe Et I-939 H 5-Br N OMe Et 125-128 I-940 Me 5-Me N OMe Et I-941 Me 5-Cl N OMe Et 134-137 I-942 Me 5-Br N OMe Et 134-141 I-943 Cl 5-Me N OMe Et I-944 Cl 5-Cl N OMe Et I-945 CF₃ 5-Me N OMe Et 86-89 I-946 CF₃ 5-Cl N OMe Et 79-82

TABLE 29 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-947 CF₃ 5-Br N OMe Et  97-100 I-948 H H N OEt Et I-949 H 5-Br N OEt Et 79-82 I-950 Me 5-Me N OEt Et I-951 Me 5-Cl N OEt Et I-952 Me 5-Br N OEt Et 96-98 I-953 Cl 5-Me N OEt Et I-954 Cl 5-Cl N OEt Et I-955 CF₃ 5-Me N OEt Et I-956 CF₃ 5-Cl N OEt Et 66-67 I-957 CF₃ 5-Br N OEt Et  97-100 I-958 H H CH OMe Pr 78-80 I-959 Me H CH OMe Pr 1.5892 I-960 Cl H CH OMe Pr 1.6009 I-961 H 5-Cl CH OMe Pr I-962 H 5-Me CH OMe Pr 116-119 I-963 Me 5-F CH OMe Pr I-964 Me 5-Cl CH OMe Pr 113-116 I-965 Me 5-Me CH OMe Pr 105-107 I-966 Me 5-OMe CH OMe Pr I-967 Me 6-Cl CH OMe Pr 68-71 I-968 Cl 5-Cl CH OMe Pr I-969 Cl 5-Me CH OMe Pr I-970 Cl 5-OMe CH OMe Pr I-971 CF₃ 5-Cl CH OMe Pr I-972 CF₃ 5-Me CH OMe Pr I-973 CF₃ 5-OMe CH OMe Pr I-974 H H CH OEt Pr I-975 H 5-Cl CH OEt Pr I-976 H 5-Me CH OEt Pr I-977 Me 5-F CH OEt Pr I-978 Me 5-Cl CH OEt Pr I-979 Me 5-Me CH OEt Pr I-980 Me 5-CF₃ CH OEt Pr

TABLE 30 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-981 Me 5-OMe CH OEt Pr I-982 Cl 5-Cl CH OEt Pr I-983 Cl 5-Me CH OEt Pr I-984 Cl 5-CF₃ CH OEt Pr I-985 Cl 5-OMe CH OEt Pr I-986 CF₃ 5-Cl CH OEt Pr I-987 CF₃ 5-Me CH OEt Pr I-988 CF₃ 5-OMe CH OEt Pr I-989 H H CH OPr Pr I-990 Me 5-Me CH OPr Pr I-991 Me 5-Cl CH OPr Pr I-992 Me 5-OMe CH OPr Pr I-993 Cl 5-Me CH OPr Pr I-994 Cl 5-Cl CH OPr Pr I-995 H H N OMe Pr I-996 H 5-Br N OMe Pr I-997 Me 5-Cl N OMe Pr I-998 Me 5-Br N OMe Pr I-999 Me 5-Me N OMe Pr 112-115 I-1000 Cl 5-Cl N OMe Pr I-1001 Cl 5-Me N OMe Pr I-1002 CF₃ 5-Cl N OMe Pr I-1003 CF₃ 5-Br N OMe Pr I-1004 CF₃ 5-Me N OMe Pr 92-95 I-1005 H H N OEt Pr I-1006 H 5-Br N OEt Pr I-1007 Me 5-Cl N OEt Pr I-1008 Me 5-Br N OEt Pr I-1009 Me 5-Me N OEt Pr I-1010 Cl 5-Cl N OEt Pr I-1011 Cl 5-Me N OPr Pr I-1012 CF₃ 5-Cl N OPr Pr I-1013 CF₃ 5-Br N OPr Pr I-1014 CF₃ 5-Me N OPr Pr

TABLE 31 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-1015 H H N OMe Pr-c I-1016 H 5-Br N OMe Pr-c 154-157 I-1017 Me 5-Cl N OMe Pr-c 116-119 I-1018 Me 5-Br N OMe Pr-c 121-124 I-1019 Me 5-Me N OMe Pr-c 167-170 I-1020 CF₃ 5-Cl N OMe Pr-c 101-104 I-1021 CF₃ 5-Br N OMe Pr-c 119-122 I-1022 CF₃ 5-Me N OMe Pr-c 116-119 I-1023 H H N OEt Pr-c I-1024 H 5-Br N OEt Pr-c 137-140 I-1025 Me 5-Cl N OEt Pr-c 130-133 I-1026 Me 5-Br N OEt Pr-c 124-127 I-1027 Me 5-Me N OEt Pr-c 131-133 I-1028 CF₃ 5-Cl N OEt Pr-c 82-85 I-1029 CF₃ 5-Br N OEt Pr-c 105-108 I-1030 CF₃ 5-Me N OEt Pr-c 79-82 I-1031 H H N SMe Pr-c I-1032 H 5-Br N SMe Pr-c I-1033 Me 5-Cl N SMe Pr-c I-1034 Me 5-Br N SMe Pr-c I-1035 Me 5-Me N SMe Pr-c I-1036 CF₃ 5-Cl N SMe Pr-c I-1037 CF₃ 5-Br N SMe Pr-c I-1038 CF₃ 5-Me N SMe Pr-c I-1039 Me H CH SMe SMe 129-131 I-1040 H 5-Cl N SMe SMe I-1041 H 5-Br N SMe SMe I-1042 Me H N SMe SMe 176-179 I-1043 Me 5-Cl N SMe SMe 186-189 I-1044 Me 5-Br N SMe SMe I-1045 Me 5-Me N SMe SMe I-1046 CF₃ 5-Cl N SMe SMe 144-146 I-1047 CF₃ 5-Br N SMe SMe I-1048 CF₃ 5-Me N SMe Me 106-109

TABLE 32 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-1049 H 5-Br N OMe SMe I-1050 Me 5-Cl N OMe SMe I-1051 Me 5-Br N OMe SMe I-1052 Me 5-Me N OMe SMe I-1053 CF₃ 5-Cl N OMe SMe I-1054 CF₃ 5-Br N OMe SMe I-1055 CF₃ 5-Me N OMe SMe I-1056 H H CH OMe Ph 160-162 I-1057 H H N OMe Ph I-1058 Me 5-Me N OMe Ph 165-168 I-1059 CF₃ 6-Me N OMe Ph 150-153 I-1060 H H CH Cl Ph 176-179 I-1061 H H N Cl Ph I-1062 H H CH Cl Cl 165-168 I-1063 Me H CH Cl Cl 170-172 I-1064 Me 5,6-Cl₂ CH Cl Cl 202-205 I-1065 H H N Cl Cl I-1066 Me H N Cl Cl >300 I-1067 H H CH Cl Me 187-190 I-1068 Me H CH Cl Me 122-125 I-1069 H H CH Cl N(Me)₂ 205-208 I-1070 H H N Cl N(Me)₂ I-1071 Me 5-Cl N N(Me)₂ N(Me)₂ 203-206 I-1072 H H CH OMe N(Me)₂ 129-132 I-1073 H H CBr OMe OMe >300 I-1074 H H CMe OMe OMe 152-155 I-1075 H H CMe Cl Cl 184-187 I-1076 H H COMe H H 131-134 I-1077 Me 5-Me COMe H H I-1078 Me 5-Cl COMe H H I-1079 H H CH Me Me 131-132 I-1080 Me 5-Cl CH Me Me 138-140 I-1081 Me 5-CF₃ CH Me Me I-1082 H H CH Me CF₃ 107-110

TABLE 33 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-1083 Me 5-Cl CH Me CF₃ I-1084 Me 5-Cl N Me CF₃ I-1085 H H CH Me Et 60-63 I-1086 H 5-Me CH Me Et 55-58 I-1087 Me 5-Me CH Me Et 109-112 I-1088 Me 5-Cl CH Me Et 76-79 I-1089 Me 5-OMe CH Me Et I-1090 Me 6-Cl CH Me Et 84-87 I-1091 Cl 5-Cl CH Me Et I-1092 Cl 5-Me CH Me Et I-1093 H H CH Et Et 58-61 I-1094 H 5-Me CH Et Et 68-71 I-1095 Me 5-Me CH Et Et 76-79 I-1096 Me 5-Cl CH Et Et 78-80 I-1097 Me 5-OMe CH Et Et I-1098 Me 6-Cl CH Et Et 80-83 I-1099 Cl 5-Cl CH Et Et I-1100 Cl 5-Me CH Et Et I-1101 H H CH Me Pr-c 124-125 I-1102 H 5-Me CH Me Pr-c I-1103 Me 5-Me CH Me Pr-c 153-156 I-1104 Me 5-Cl CH Me Pr-c 119-122 I-1105 Me 5-OMe CH Me Pr-c I-1106 Me 6-Cl CH Me Pr-c 110-113 I-1107 Cl 5-Cl CH Me Pr-c I-1108 Cl 5-Me CH Me Pr-c I-1109 H H CH Et Pr-c I-1110 Me 5-Me CH Et Pr-c I-1111 Me 5-Cl CH Et Pr-c I-1112 Me 5-OMe CH Et Pr-c I-1113 Me 6-Cl CH Et Pr-c I-1114 Cl 5-Cl CH Et Pr-c I-1115 Cl 5-Me CH Et Pr-c I-1116 H H CH Et Et

TABLE 34 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-1117 Me 5-Me CH Et Et I-1118 Me 5-Cl CH Et Et I-1119 Me 5-OMe CH Et Et I-1120 Me 6-Cl CH Et Et I-1121 Cl 5-Cl CH Et Et I-1122 Cl 5-Me CH Et Et I-1123 H H CH C≡CMe Me 134-136 I-1124 Me 5-Me CH C≡CMe Me I-1125 Me 5-Cl CH C≡CMe Me I-1126 Me 5-Me N C≡CMe Me I-1127 Me 5-Cl N C≡CMe Me I-1128 Cl 5-Cl CH C≡CMe Me I-1129 Cl 5-Me CH C≡CMe Me I-1130 H H CH CH═CH₂ Me I-1131 Me 5-Me CH CH═CH₂ Me I-1132 Me 5-Cl CH CH═CH₂ Me I-1133 Me 5-Me N CH═CH₂ Me I-1134 Cl 5-Cl CH CH═CH₂ Me I-1135 Cl 5-Me CH CH═CH₂ Me I-1136 H H CH CHO Me I-1137 Me 5-Cl CH CHO Me I-1138 Me 5-Cl N CHO Me I-1139 H H CH COMe Me I-1140 Me 5-Cl CH COMe Me I-1141 Me 5-Cl N COMe Me I-1142 H H CH CH₂OMe Me I-1143 Me 5-Cl CH CH₂OMe Me I-1144 Me 5-Me CH CH₂OMe Me I-1145 H H N CH₂OMe OMe I-1146 Me H CH CN CN I-1147 Me H CH CN Me 187-189 I-1148 Me H N CN CN I-1149 Me H N CN Me I-1150 Me H CH SO₂Me SO₂Me

TABLE 35 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) I-1151 Me H N SO₂Me SO₂Me I-1152 Me H CH SO₂Me Me 183-186

Typical processes for producing pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives represented by the general formula [I] as the compounds of the present invention, will be exemplified below.

(wherein X, Y, R¹, R², A and n have the same meanings as mentioned above respectively, and L is a leaving group such as a halogen atom, a (C₁-C₆) alkylsulfonyl group or a benzylsulfonyl group.)

The compound of the present invention represented by the general formula [I] can be produced by reacting a benzimidazole derivative represented by the general formula [II] and a pyrimidine derivative or triazine derivative represented by the general formula [III] in the presence of a base in a solvent. Here, as the base, a carbonate, hydrogencarbonate, acetate, alcoholate, hydroxide, hydride or oxide of an alkali metal or alkaline earth metal, particularly sodium, potassium, magnesium or calcium, may, for example, be used. The solvent which can be used in the present reaction may be one which does not inhibit the progress of the present reaction, and an ether such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, monoglyme or diglyme, a halogenated hydrocarbon such as dichloroethane, chloroform, carbon tetrachloride or tetrachloroethane, an aromatic hydrocarbon such as benzene, chlorobenzene, nitrobenzene or toluene, or N,N-dimethylformamide, N,N-dimethylacetoamide, 1,3-dimethyl-2-imidazolinone or dimethylsulfoxide, may, for example, be used. These inert solvents may be used alone or as mixed. The reaction temperature may be selected within a range of from −20° C. to the boiling point of the inert solvent to be used, and preferably within a range of from 0° C. to 80° C. The reaction time varies depending upon e.g. the reaction temperature and the reaction amount, but may be selected within a range of from 1 hour to 48 hours in general. After completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires.

Here, the benzimidazole derivative represented by the general formula [II] may be a commercially available product or may be produced by a known method [e.g. a method as disclosed in Angewandte Chemie, vol 85, p866 (1973); Journal of the American Chemical Society, vol 69, p2459 (1947); Journal of the American Chemical Society, vol 82, p3138 (1960); Organic Syntheses, vol 2, p65 (1943); or Organic Syntheses, vol 4, p569 (1963)].

(wherein X, Y, R¹, R², A and n have the same meanings as mentioned above respectively.)

The anilide derivative represented by the general formula [V] can be produced by reacting an anilinopyrimidine derivative or anilinotriazine derivative represented by the general formula [IV] with an acylating agent in an inert solvent. The reaction is carried out preferably in the presence of a base. As the acylating agent, an acid halide such as acetyl chloride, propionyl chloride or benzoyl chloride, or an acid anhydride such as trifluoroacetic anhydride, propionic anhydride or benzoic anhydride may be mentioned. The inert solvent which can be used in the present reaction may be one which does not inhibit the progress of the present reaction, and for example, e.g. a ketone such as acetone, methyl ethyl ketone or cyclohexanone, an ether such as diethyl ether, diisopropyl ether, tetrahydrofuran, dioxane, monoglyme or diglyme, an ester such as ethyl acetate or methyl acetate, a halogenated hydrocarbon such as dichloroethane, chloroform, carbon tetrachloride or tetrachloroethane, an aromatic hydrocarbon such as benzene, chlorobenzene, nitrobenzene or toluene, a nitrile such as acetonitrile, or N,N-dimethylformamide, N,N-dimethylacetoamide, 1,3-dimethyl-2-imidazolinone, dimethylsulfoxide, pyridine or water, may be used. These inert solvents may be used alone or as mixed. As the base to be used in the present reaction, an inorganic base or an organic base may be used. For example, as an inorganic base, a carbonate or hydroxide of an alkali metal or alkaline earth metal, such as sodium carbonate, potassium carbonate, calcium carbonate, sodium hydrogencarbonate, sodium hydroxide, potassium hydroxide or calcium hydroxide, or a hydride of an alkali metal such as lithium hydride or sodium hydride, may be used, and as an organic base, triethylamine, diisopropylethylamine or pyridine may, for example, be used. The reaction temperature may be selected within a range of from −20° C. to the boiling point of the inert solvent to be used, and preferably within a range of from 0° C. to 50° C. The reaction time varies depending upon e.g. the reaction temperature and the reaction amount, but may be selected within a range of from several minutes to 48 hours in general.

Then, the anilide derivative represented by the general formula [V] is subjected to a cyclization reaction without a solvent or in a solvent, in the presence of a catalyst as the case requires, to produce the compound of the present invention represented by the general formula [I]. As the catalyst to be used here, an inorganic acid such as sulfuric acid or hydrochloric acid or an organic acid such as para-toluenesulfonic acid may, for example, be used. As the solvent which can be used in the present reaction, the solvent exemplified in Process 1 may be used. The reaction temperature may be selected within a range of from 0° C. to the boiling point of the solvent to be used, and preferably within a range of from room temperature to the boiling point of the solvent. The reaction time varies depending upon e.g. the reaction temperature and the reaction amount, but may be selected within a range of from 1 hour to 48 hours in general. After the completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires.

(wherein X, Y, R¹, R², A and n have the same meanings as mentioned above respectively.)

The compound of the present invention represented by the general formula [I] can be produced directly by heating an anilinopyrimidine derivative or anilinotriazine derivative represented by the general formula [IV] in a carboxylic acid represented by the general formula [VI], in the presence of an acid anhydride as the case requires. The reaction temperature may be selected within a range of from 0° C. to the boiling point of the carboxylic acid to be used, preferably within a range of from room temperature to the boiling point of the carboxylic acid. The reaction time may be selected within a range of from 1 hour to 48 hours in general. After the completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires.

(wherein Y, R¹, R², A and n have the same meanings as mentioned above respectively.)

The compound represented by the general formula [I-a] can be produced by reacting an anilinopyrimidine derivative or anilinotriazine derivative represented by the general formula [IV] and a reagent [VII] such as BrCN or H₂NCN by a method known from a literature [e.g. a method as disclosed in Journal of the American Chemical Society, vol 69, p2459 (1947); or Angewandte Chemie, vol 85, p866 (1973)] in a solvent. As the solvent which can be used in the present reaction, the solvent as exemplified in Process 1 may be used. The reaction temperature may be selected within a range of from −20° C. to the boiling point of the reaction mixture to be used, preferably within a range of from 0° C. to the boiling point of the reaction mixture. The reaction time varies depending upon e.g. the reaction temperature or the reaction amount, and may be selected within a range of from 1 hour to 48 hours in general. After the completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires.

(wherein X′ is a halogen atom, and Y, R¹, R², A and n have the same meanings as mentioned above respectively.)

The compound represented by the general formula [I-d] can be produced by diazotizing a 2-aminobenzimidazole derivative represented by the general formula [I-a] by a known method [e.g. Sandmeyer method, Schwechten method or Gattermann method] in a solvent at a reaction temperature which are conventionally employed, followed by halogenation. After the completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires.

(wherein Y, R¹, R², A and n have the same meanings as mentioned above respectively, and R⁴ is a C₁-C₆ alkyl group.)

The compound represented by the general formula [I-e] can be produced by oxidizing a pyrimidinylbenzimidazole derivative or triazinylbenzimidazole derivative represented by the general formula [I-b] by a known method. After the completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires. The oxidizing agent which can be used in the present reaction may, for example, be hydrogen peroxide or an organic peracid such as m-chloroperbenzoic acid. As the solvent which can be used, the solvent as exemplified in Process 1 may be used. The reaction temperature may be selected within a range of from −20° C. to the boiling point of the reaction mixture to be used, preferably within a range of from 5° C. to the boiling point of the reaction mixture. After the completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires.

(wherein Y, R¹, R², A, L and n have the same meanings as mentioned above respectively, and X″ is a (C₁-C₆) alkoxy, (C₂-C₆) alkenyloxy, (C₂-C₆) alkynyloxy, (C₁-C₆) alkylthio or (C₁-C₆) alkylamino group.)

The compound of the present invention represented by the general formula [I-f] can be produced by reacting a pyrimidinylbenzimidazole derivative or triazinylbenzimidazole derivative represented by the general formula [I-c] and an alcohol, mercaptan or amine represented by the general formula [XVI] in the presence of a base without a solvent or in a solvent. As the base and the solvent which can be used in the present reaction, the base and the solvent as exemplified in Process 1 may be used. The reaction temperature may be selected within a range of from −20° C. to the boiling point of the reaction mixture to be used, preferably within a range of from room temperature to the boiling point of the reaction mixture. After the completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires.

(wherein X, Y, A, L and n have the same meanings as mentioned above respectively, and Z is a (C₁-C₆) alkoxy, (C₂-C₆) alkenyloxy, (C₂-C₆) alkynloxy, (C₁-C₆) alkylthio or di (C₁-C₆) alkylamino group.)

The compound of the present invention represented by the general formula [I-h] can be produced by reacting a pyrimidinylbenzimidazole derivative or triazinylbenzimidazole derivative represented by the general formula [I-g] and an alcohol, mercaptan or amine represented by the general formula [VIII] in the presence of a base without a solvent or in a proper solvent. As the base and the solvent which can be used in the present reaction, the base and the solvent as exemplified in Process 1 may be used. The reaction temperature may be selected within a range of from −20° C. to the boiling point of the reaction mixture to be used, preferably within a range of from room temperature to the boiling point of the reaction mixture. After the completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires.

(wherein Y, R¹, R², A and n have the same meanings as mentioned above respectively.)

The compound of the present invention represented by the general formula [I-i] can be produced by reducing an anilinotriazine derivative represented by the general formula [IX] with iron powder in acetic acid or in a mixed solvent of acetic anhydride and acetic acid. The reaction temperature may be selected within a range of from −20° C. to the boiling point of the reaction mixture to be used, preferably within a range of from room temperature to the boiling point of the reaction mixture. After the completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires.

Now, processes for synthesizing the production intermediates for the compounds of the present invention will be explained in detail below.

Process 10

Synthesis of Production Intermediate Represented by the General Formula [IV]

The compound [IV] may be synthesized, for example, in accordance with the following process, but the process is not limited thereto.

(wherein Y, R¹, R², A, L and n have the same meanings as mentioned above respectively.)

A formanilide derivative represented by the general formula [X] and a pyrimidine derivative or triazine derivative represented by the general formula [III] are reacted in the presence of a base in an inert solvent at a reaction temperature within a range of from −20° C. to the boiling point of the solvent, preferably within a range of from room temperature to 80° C., followed by hydrolysis with e.g. an acid such as hydrochloric acid, hydrobromic acid or sulfuric acid or an alkali metal hydroxide such as sodium hydroxide or potassium hydroxide by a generally known method to obtain [XI]. Then, the obtained [XI] is reduced with a reducing agent such as iron, tin chloride, or a hydrogen atom accompanied with another catalyst such as palladium carbon or Raney Nickel, by a generally known method to produce an anilinopyrimidine derivative or anilinotriazine derivative represented by the general formula [IV].

Process 11

Synthesis of Production Intermediate Represented by the General Formula [XI-b]

The compound [XI-b] may be synthesized, for example, in accordance with the following process, but the process is not limited thereto.

(wherein Y, Z and n have the same meanings as mentioned above respectively.)

A nitroaniline derivative represented by the general formula [XII] and cyanuric chloride represented by [XIII] are reacted in the presence of a base without a solvent or in a proper solvent to produce an anilinotriazine derivative represented by the general formula [XI-a], which is successively reacted with an alcohol, mercaptan or amine represented by the general formula [VIII] in the presence of a base without a solvent or in a proper solvent to produce an anilinotriazine derivative represented by the general formula [XI-b]. As the base and the solvent which can be used in the present reaction, the base and the solvent as exemplified in Process 1 may be used. The reaction temperature may be selected within a range of from −20° C. to the boiling point of the reaction mixture to be used, preferably within a range of from room temperature to the boiling point of the reaction mixture. After the completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires.

Process 12

Synthesis of Production Intermediates Represented by the General Formulae [XI-c] and [XI-d]

The compounds [XI-c] and [XI-d] may be synthesized, for example, in accordance with the following process, but the process is not limited thereto.

(wherein R¹, Y, L, Z and n have the same meanings as mentioned above respectively.)

A formanilide derivative represented by the general formula [X] and a triazine derivative represented by [XIV] are reacted in the presence of a base without a solvent or in a proper solvent, followed by hydrolysis with e.g. an acid such as hydrochloric acid, hydrobromic acid or sulfuric acid or an alkali metal hydroxide such as sodium hydroxide or potassium hydroxide, by a generally known method to produce an anilinotriazine derivative represented by the general formula [XI-c], which is successively reacted with an alcohol, mercaptan or amine represented by the general formula [VIII] in the presence of a base without a solvent or in a proper solvent to produce an anilinotriazine derivative represented by the general formula [XI-d]. As the base and the solvent which can be used in the present reaction, the base and the solvent as exemplified in Process 1 may be used. The reaction temperature may be selected within a range of from −20° C. to the boiling point of the reaction mixture to be used, preferably within a range of from room temperature to the boiling point of the reaction mixture. After the completion of the reaction, the desired product is isolated from the reaction system by a conventional method and may be purified by e.g. column chromatography or recrystallization, as the case requires.

Here, the anilinopyrimidine and anilinotriazine derivatives represented by the general formulae [IV], [V] and [XI] are also novel compounds, and specific examples thereof will be disclosed in Tables 36 to 65.

TABLE 36

m.p. (° C.) Compound or RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-1 H H CH OMe OMe 1-2 Me H CH OMe OMe 1-3 Et H CH OMe OMe 1-4 Pr H CH OMe OMe 1-5 Pr-i H CH OMe OMe 1-6 Pr-c H CH OMe OMe 1-7 Bu H CH OMe OMe 1-8 Bn H CH OMe OMe 169-172 1-9 Bn(4-Cl) H CH OMe OMe 187-200 1-10 Bn(4-Me) H CH OMe OMe 157-158 1-11 Bn(4-OMe) H CH OMe OMe 1-12 CH═CH₂ H CH OMe OMe 147-149 1-13 C≡CH H CH OMe OMe 1-14 CH₂OEt H CH OMe OMe 1-15 CH₂Cl H CH OMe OMe 125-126 1-16 CH₂CH₂Cl H CH OMe OMe 162-165 1-17 CH₂I H CH OMe OMe 1-18 CCl₃ H CH OMe OMe 1-19 CF₃ H CH OMe OMe 1-20 C₂F₅ H CH OMe OMe 82-85 1-21 Ph H CH OMe OMe 148-152 1-22 Ph(4-Cl) H CH OMe OMe 1-23 Ph(4-Me) H CH OMe OMe 1-24 Ph(4-OMe) H CH OMe OMe 1-25 H H N OMe OMe 1-26 Me H N OMe OMe

TABLE 37 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-27 Et H N OMe OMe 1-28 Pr H N OMe OMe 1-29 Pr-i H N OMe OMe 1-30 Pr-c H N OMe OMe 1-31 Bu H N OMe OMe 1-32 Bn H N OMe OMe 1-33 Bn(4-Cl) H N OMe OMe 1-34 Bn(4-Me) H N OMe OMe 1-35 Bn(4-OMe) H N OMe OMe 1-36 CH═CH₂ H N OMe OMe 1-37 C≡CH H N OMe OMe 1-38 CH₂OEt H N OMe OMe 1-39 CH₂Cl H N OMe OMe 1-40 CH₂I H N OMe OMe 1-41 CCl₃ H N OMe OMe 1-42 CF₃ H N OMe OMe 1-43 C₂F₅ H N OMe OMe 1-44 Ph H N OMe OMe 1-45 Ph(4-Cl) H N OMe OMe 1-46 Ph(4-Me) H N OMe OMe 1-47 Ph(OMe) H N OMe OMe 1-48 H 6-Me CH OMe OMe 1-49 H 6-Cl CH OMe OMe 1-50 H 5-F CH OMe OMe 1-51 H 5-Cl CH OMe OMe 1-52 H 5-Br CH OMe OMe 1-53 H 5-Me CH OMe OMe 1-54 H 5-Bu-t CH OMe OMe 1-55 H 5-CF₃ CH OMe OMe 1-56 H 5-OMe CH OMe OMe 1-57 H 5-OEt CH OMe OMe 1-58 H 5-OPr CH OMe OMe 1-59 H 5-OCF₃ CH OMe OMe

TABLE 38 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-60 H 5-OCH₂CH═CH₂ CH OMe OMe 1-61 H 5-OCH₂C≡CH CH OMe OMe 1-62 H 5-OPh CH OMe OMe 1-63 H 5-OPh(4-Cl) CH OMe OMe 1-64 H 5-OPh(4-Me) CH OMe OMe 1-65 H 5-OPh(4-OMe) CH OMe OMe 1-66 H 5-SMe CH OMe OMe 1-67 H 5-CH₂OMe CH OMe OMe 1-68 H 5-COMe CH OMe OMe 1-69 H 5-COPh CH OMe OMe 1-70 H 5-CO₂Et CH OMe OMe 1-71 H 5-Ph CH OMe OMe 1-72 H 5-Ph(4-Cl) CH OMe OMe 1-73 H 5-Ph(4-Me) CH OMe OMe 1-74 H 5-Ph(4-OMe) CH OMe OMe 1-75 H 5-NO₂ CH OMe OMe 1-76 H 5-NH₂ CH OMe OMe 1-77 H 5-NHMe CH OMe OMe 1-78 H 5-NMe₂ CH OMe OMe 1-79 H 5-CN CH OMe OMe 1-80 H 4-F CH OMe OMe 1-81 H 4-Cl CH OMe OMe 1-82 H 4-Me CH OMe OMe 1-83 H 4-CF₃ CH OMe OMe 1-84 H 4-OMe CH OMe OMe 1-85 H 4-CO₂Et CH OMe OMe 1-86 H 4-COPh CH OMe OMe 1-87 H 3-Me CH OMe OMe 1-88 H 3-Cl CH OMe OMe 1-89 H 4,5-Cl₂ CH OMe OMe 1-90 H 4,5-Me₂ CH OMe OMe 1-91 H 4,5-(OMe)₂ CH OMe OMe 1-92 H 4-CF₃, 6-Br CH OMe OMe

TABLE 39 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-93 H 4-CF₃, 6-Cl CH OMe OMe 1-94 H 4,5,6-F₃ CH OMe OMe 1-95 H 6-Me N OMe OMe 1-96 H 6-Cl N OMe OMe 1-97 H 5-F N OMe OMe 1-98 H 5-Cl N OMe OMe 1-99 H 5-Br N OMe OMe 1-100 H 5-Me N OMe OMe 1-101 H 5-CF₃ N OMe OMe 1-102 H 5-OMe N OMe OMe 1-103 H 5-OEt N OMe OMe 1-104 H 5-OPr N OMe OMe 1-105 H 5-OCF₃ N OMe OMe 1-106 H 5-OCH₂CH═CH₂ N OMe OMe 1-107 H 5-OCH₂C≡CH N OMe OMe 1-108 H 5-OPh N OMe OMe 1-109 H 5-SMe N OMe OMe 1-110 H 5-COPh N OMe OMe 1-111 H 5-CO₂Et N OMe OMe 1-112 H 5-Ph N OMe OMe 1-113 H 5-Ph(4-Cl) N OMe OMe 1-114 H 5-Ph(4-Me) N OMe OMe 1-115 H 5-Ph(4-OMe) N OMe OMe 1-116 H 5-NO₂ N OMe OMe 1-117 H 5-NH₂ N OMe OMe 1-118 H 5-NHMe N OMe OMe 1-119 H 5-NMe₂ N OMe OMe 1-120 H 5-CN N OMe OMe 1-121 H 4-F N OMe OMe 1-122 H 4-Cl N OMe OMe 1-123 H 4-Me N OMe OMe 1-124 H 4-CF₃ N OMe OMe 1-125 H 4-OMe N OMe OMe

TABLE 40 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-126 H 4-NO₂ N OMe OMe 1-127 H 4-CO₂Et N OMe OMe 1-128 H 4-COPh N OMe OMe 1-129 H 3-Me N OMe OMe 1-130 H 3-Cl N OMe OMe 1-131 H 4,5-Cl₂ N OMe OMe 1-132 H 4,5-Me₂ N OMe OMe 1-133 H 4,5-(OMe)₂ N OMe OMe 1-134 H 4-CF₃, 6-Br N OMe OMe 1-135 H 4-CF₃, 6-Cl N OMe OMe 1-136 H 4,5,6-F₃ N OMe OMe 1-137 Me 6-Me CH OMe OMe 1-138 Me 6-Cl CH OMe OMe 1-139 Me 6-F CH OMe OMe 1-140 Me 5-Cl CH OMe OMe 1-141 Me 5-Br CH OMe OMe 1-142 Me 5-Me CH OMe OMe 1-143 Me 5-Bu-t CH OMe OMe 1-144 Me 5-CF₃ CH OMe OMe 1-145 Me 5-OMe CH OMe OMe 1-146 Me 5-COPh CH OMe OMe 1-147 Me 5-Ph CH OMe OMe 1-148 Me 5-NH₂ CH OMe OMe 1-149 Me 5-NMe₂ CH OMe OMe 1-150 Me 5-CN CH OMe OMe 1-151 Me 4-F CH OMe OMe 1-152 Me 4-Cl CH OMe OMe 1-153 Me 4-Me CH OMe OMe 1-154 Me 4-CF₃ CH OMe OMe 1-155 Me 4-OMe CH OMe OMe 1-156 Me 4-COPh CH OMe OMe 1-157 Me 4,5-Cl₂ CH OMe OMe 1-158 Me 4,5-Me₂ CH OMe OMe

TABLE 41 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-159 Me 4,5-(OMe)₂ CH OMe OMe 1-160 Me 6-Me N OMe OMe 1-161 Me 6-Cl N OMe OMe 1-162 Me 5-F N OMe OMe 1-163 Me 5-Cl N OMe OMe 1-164 Me 5-Br N OMe OMe 1-165 Me 5-Me N OMe OMe 180-183 1-166 Me 5-Et N OMe OMe 1-167 Me 5-Pr N OMe OMe 1-168 Me 5-Pr-i N OMe OMe 1-169 Me 5-Bu-t N OMe OMe 1-170 Me 5-CH═CH₂ N OMe OMe 1-171 Me 5-C≡CBu N OMe OMe 1-172 Me 5-CF₃ N OMe OMe 1-173 Me 5-OMe N OMe OMe 1-174 Me 5-SMe N OMe OMe 1-175 Me 5-COPh N OMe OMe 1-176 Me 5-Ph N OMe OMe 1-177 Me 5-NH₂ N OMe OMe 1-178 Me 5-NMe₂ N OMe OMe 1-179 Me 5-CN N OMe OMe 1-180 Me 4-F N OMe OMe 1-181 Me 4-Cl N OMe OMe 1-182 Me 4-Me N OMe OMe 1-183 Me 4-CF₃ N OMe OMe 1-184 Me 4-OMe N OMe OMe 1-185 Me 4-OEt N OMe OMe 1-186 Me 4-OPr N OMe OMe 1-187 Me 4-CO₂Et N OMe OMe 1-188 Me 4-COPh N OMe OMe 1-189 Me 4,5-Cl₂ N OMe OMe 1-190 Me 4,6-Me₂ N OMe OMe 1-191 Me 4,5-Me₂ N OMe OMe

TABLE 42 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-192 Me 4,5-(OMe)₂ N OMe OMe 1-193 CF₃ 5-F CH OMe OMe 158-160 1-194 CF₃ 5-Cl CH OMe OMe 150-151 1-195 CF₃ 5-Br CH OMe OMe 1-196 CF₃ 5-Me CH OMe OMe 144-147 1-197 CF₃ 5-CF₃ CH OMe OMe 168-171 1-198 CF₃ 5-OMe CH OMe OMe 1-199 CF₃ 5-OEt CH OMe OMe 122-125 1-200 CF₃ 5-OPr CH OMe OMe 1-201 CF₃ 5-NMe₂ CH OMe OMe 1-202 CF₃ 5-CN CH OMe OMe 1-203 CF₃ 4-F CH OMe OMe 1-204 CF₃ 4-Cl CH OMe OMe 1-205 CF₃ 4-Me CH OMe OMe 1-206 CF₃ 4,5-(OMe)₂ CH OMe OMe 1-207 CF₃ 5-F N OMe OMe 202-205 1-208 CF₃ 5-Cl N OMe OMe 1-209 CF₃ 5-Br N OMe OMe 1-210 CF₃ 5-Me N OMe OMe 195-198 1-211 CF₃ 5-Et N OMe OMe 182-185 1-212 CF₃ 5-Pr N OMe OMe 141-144 1-213 CF₃ 5-Pr-i N OMe OMe 193-196 1-214 CF₃ 5-Bu-t N OMe OMe 215-218 1-215 CF₃ 5-CF₃ N OMe OMe 1-216 CF₃ 5-OMe N OMe OMe 183-185 1-217 CF₃ 5-OEt N OMe OMe 1-218 CF₃ 5-OPr N OMe OMe 1-219 CF₃ 5-OCF₃ N OMe OMe 188-191 1-220 CF₃ 5-SMe N OMe OMe 1-221 CF₃ 5-NHMe N OMe OMe 1-222 CF₃ 5-NMe₂ N OMe OMe 1-223 CF₃ 5-CN N OMe OMe 1-224 CF₃ 5-CO₂Me N OMe OMe 186-189

TABLE 43 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-225 CF₃ 5-I N OMe OMe 169-172 1-226 CF₃ 4-F N OMe OMe 1-227 CF₃ 4-Cl N OMe OMe 1-228 CF₃ 6-Me N OMe OMe 1-229 CF₃ 4,5-(OMe)₂ N OMe OMe 1-230 Et 5-F CH OMe OMe 1-231 Et 5-Cl CH OMe OMe 1-232 Et 5-Me CH OMe OMe 1-233 Et 5-CF₃ CH OMe OMe 1-234 Et 5-OMe CH OMe OMe 1-235 Et 5-CN CH OMe OMe 1-236 Et 4-F CH OMe OMe 1-237 Et 4-Cl CH OMe OMe 1-238 Et 4-Me CH OMe OMe 1-239 Et 4,5-(OMe)₂ CH OMe OMe 1-240 Et 5-F N OMe OMe 1-241 Et 5-Cl N OMe OMe 1-242 Et 5-Me N OMe OMe 1-243 Et 5-CF₃ N OMe OMe 1-244 Et 5-OMe N OMe OMe 1-245 Et 5-CN N OMe OMe 1-246 Et 4-F N OMe OMe 1-247 Et 4-Cl N OMe OMe 1-248 Et 4-Me N OMe OMe 1-249 Et 4,5-(OMe)₂ N OMe OMe 1-250 Pr 5-Cl N OMe OMe 137-140 1-251 Pr-i 5-Cl N OMe OMe 149-152 1-252 Pr-c 5-Cl N OMe OMe 181-184 1-253 CH₂OMe 5-Cl N OMe OMe 1-254 Ph 5-Cl N OMe OMe 176-179 1-255 Ph 5-Br N OMe OMe 1-256 Ph(4-Cl) 5-Cl N OMe OMe 1-257 Ph(4-Me) 5-Cl N OMe OMe

TABLE 44 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-258 Ph(4-OMe) 5-Cl N OMe OMe 1-259 Bn 5-Cl N OMe OMe 1-260 CF₂Cl 5-Me N OMe OMe 1-261 CF₂Cl 5-Cl N OMe OMe 1-262 CF₂Cl 5-Br N OMe OMe 1-263 CF₂Cl 5-OMe N OMe OMe 1-264 CH₂Cl 5-Me N OMe OMe 1-265 CH₂Cl 5-Cl N OMe OMe 1-266 CH₂Cl 5-Br N OMe OMe 1-267 CH₂Cl 5-OMe N OMe OMe 1-268 C₂F₅ 5-Me N OMe OMe 1-269 C₂F₅ 5-Cl N OMe OMe 1-270 C₂F₅ 5-Br N OMe OMe 1-271 C₂F₅ 5-OMe N OMe OMe 1-272 Ph(4-Cl) 5-OMe CH OMe OMe 187-200 1-273 CH₂OMe 5-Cl N OMe OMe 183-186 1-274 CF₃ 5-Me N OMe OEt 1-275 CF₃ 5-Cl N OMe OEt 1-276 CF₃ 5-Br N OMe OEt 1-277 CF₂Cl 5-Cl N OMe OEt 1-278 CF₂Cl 5-Br N OMe OEt 1-279 CF₂Cl 5-Me N OMe OEt 1-280 CH₂Cl 5-Cl N OMe OEt 1-281 CH₂Cl 5-Br N OMe OEt 1-282 CH₂Cl 5-Me N OMe OEt 1-283 C₂F₅ 5-Cl N OMe OEt 1-284 C₂F₅ 5-Br N OMe OEt 1-285 C₂F₅ 5-Me N OMe OEt 1-286 Me 5-F CH OEt OEt 1-287 Me 5-Cl CH OEt OEt 1-288 Me 5-Br CH OEt OEt 1-289 Me 5-Me CH OEt OEt 1-290 Me 5-CF₃ CH OEt OEt

TABLE 45 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-291 Me 5-F N OEt OEt 1-292 Me 5-Cl N OEt OEt 1-293 Me 5-Br N OEt OEt 1-294 Me 5-Me N OEt OEt 1-295 Me 5-CF₃ N OEt OEt 1-296 CF₃ 5-F CH OEt OEt 1-297 CF₃ 5-Cl CH OEt OEt 1-298 CF₃ 5-Br CH OEt OEt 1-299 CF₃ 5-Me CH OEt OEt 1-300 CF₃ 5-CF₃ CH OEt OEt 1-301 CF₃ 5-OMe N OEt OEt 159-161 1-302 CF₃ 5-Cl N OEt OEt 194-197 1-303 CF₃ 5-Br N OEt OEt 191-194 1-304 CF₃ 5-Me N OEt OEt 201-204 1-305 CF₃ 5-CF₃ N OEt OEt 1-306 Ph H N OEt OEt 1-307 Ph(4-Cl) H N OEt OEt 1-308 Ph(4-Me) H N OEt OEt 1-309 Ph(4-OMe) H N OEt OEt 1-310 Ph 5-Cl N OEt OEt 1-311 Ph(4-Cl) 5-Cl N OEt OEt 1-312 Ph(4-Me) 5-Cl N OEt OEt 1-313 Ph(4-OMe) 5-Cl N OEt OEt 1-314 Ph 5-Br N OEt OEt 1-315 Ph(4-Cl) 5-Br N OEt OEt 1-316 Ph(4-Me) 5-Br N OEt OEt 1-317 Ph(4-OMe) 5-Br N OEt OEt 1-318 H H CH OPr OPr 1-319 Me 5-Cl N OPr OPr 1-320 Me 5-Br N OPr OPr 1-321 Me 5-Me N OPr OPr 1-322 CF₃ 5-Cl N OPr OPr 150-153 1-323 CF₃ 5-Br N OPr OPr

TABLE 46 Compound m.p. (° C.) or No. X Yn A R¹ R² RI (n_(D) ²⁰) 1-324 CF₃ 5-Me N OPr OPr 1-325 H H CH OPr-i OPr-i 1-326 Me 5-Cl CH OPr-i OPr-i 1-327 Me 5-Me CH OPr-i OPr-i 1-328 Me 5-Cl N OPr-i OPr-i 1-329 Me 5-Br N OPr-i OPr-i 1-330 Me 5-Me N OPr-i OPr-i 1-331 CF₃ 5-Cl N OPr-i OPr-i 198-201 1-332 CF₃ 5-Br N OPr-i OPr-i 1-333 CF₃ 5-Me N OPr-i OPr-i 1-334 Me 5-Cl N OCH₂CH═CH₂ OCH₂CH═CH₂ 1-335 Me 5-Br N OCH₂CH═CH₂ OCH₂CH═CH₂ 1-336 Me 5-Me N OCH₂CH═CH₂ OCH₂CH═CH₂ 1-337 CF₃ 5-Cl N OCH₂CH═CH₂ OCH₂CH═CH₂ 121-124 1-338 CF₃ 5-Br N OCH₂CH═CH₂ OCH₂CH═CH₂ 1-339 CF₃ 5-Me N OCH₂CH═CH₂ OCH₂CH═CH₂ 1-340 Me 5-Cl N OCH₂C≡CH OCH₂C≡CH 1-341 Me 5-Br N OCH₂C≡CH OCH₂C≡CH 1-342 Me 5-Me N OCH₂C≡CH OCH₂C≡CH 1-343 CF₃ 5-Cl N OCH₂C≡CH OCH₂C≡CH 1-344 CF₃ 5-Br N OCH₂C≡CH OCH₂C≡CH 1-345 CF₃ 5-Me N OCH₂C≡CH OCH₂C≡CH 1-346 Me 5-Cl CH OCH₂CN OCH₂CN 1-347 Me 5-Me CH OCH₂CN OCH₂CN 1-348 Me 5-Cl N OCH₂CN OCH₂CN 1-349 Me 5-Br N OCH₂CN OCH₂CN 1-350 Me 5-Me N OCH₂CN OCH₂CN 1-351 CF₃ 5-Cl N OCH₂CN OCH₂CN 1-352 CF₃ 5-Br N OCH₂CN OCH₂CN 1-353 CF₃ 5-Me N OCH₂CN OCH₂CN 1-354 Me 5-Cl CH OCH₂CH₂OMe OCH₂CH₂OMe 1-355 Me 5-Me CH OCH₂CH₂OMe OCH₂CH₂OMe 1-356 H 5-Br N OCH₂CH₂OMe OCH₂CH₂OMe

TABLE 47 m.p. (° C.) or Compound No. X Yn A R¹ R² RI (n_(D) ²⁰) 1-357 Me 5-Cl N OCH₂CH₂OMe OCH₂CH₂OMe 1-358 Me 5-Br N OCH₂CH₂OMe OCH₂CH₂OMe 1-359 Me 5-Me N OCH₂CH₂OMe OCH₂CH₂OMe 1-360 CF₃ 5-Cl N OCH₂CH₂OMe OCH₂CH₂OMe 1-361 CF₃ 5-Br N OCH₂CH₂OMe OCH₂CH₂OMe 1-362 CF₃ 5-Me N OCH₂CH₂OMe OCH₂CH₂OMe 1-363 H 5-Br N OCH₂Pr-c OCH₂Pr-c 1-364 Me 5-Cl N OCH₂Pr-c OCH₂Pr-c 1-365 Me 5-Br N OCH₂Pr-c OCH₂Pr-c 1-366 Me 5-Me N OCH₂Pr-c OCH₂Pr-c 1-367 CF₃ 5-Cl N OCH₂Pr-c OCH₂Pr-c 1-368 CF₃ 5-Br N OCH₂Pr-c OCH₂Pr-c 1-369 CF₃ 5-Me N OCH₂Pr-c OCH₂Pr-c 1-370 H H CH OBn OBn 1-371 H H N OBn OBn 1-372 H H N OBn(4-Cl) OBn(4-Cl) 1-373 H H N OBn(4-Me) OBn(4-Me) 1-374 H H N OBn(4-OMe) OBn(4-OMe) 1-375 H H CH OMe OPh 1-376 H H N OMe OPh 1-377 H H N OMe OPh(4-Cl) 1-378 H H N OMe OPh(4-Me) 1-379 H H N OMe OPh(4-OMe) 1-380 H H CH OMe OCHF₂ 1-381 H H N OMe OCHF₂ 1-382 Me 5-Cl CH OMe H 1-383 Me 5-Me CH OMe H 1-384 Me 5-CF₃ CH OMe H 1-385 Me 5-OMe CH OMe H 1-386 CF₃ 5-Cl CH OMe H 125-128 1-387 CF₃ 5-Me CH OMe H 130-133 1-388 CF₃ 5-CF₃ CH OMe H 1-389 CF₃ 5-OMe CH OMe H 153-156

TABLE 48 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-390 CF₃ 5-Cl CH OEt H 1-391 CF₃ 5-Me CH OEt H 125-127 1-392 CF₃ 5-OMe CH OEt H 1-393 Me 5-Cl CH OMe Me 1-394 Me 5-Me CH OMe Me 1-395 Me 5-CF₃ CH OMe Me 1-396 CF₃ 5-Cl CH OMe Me 1-397 CF₃ 5-Me CH OMe Me 1-398 CF₃ 5-OMe CH OMe Me 1-399 Me 5-Cl N OMe Me 1-400 Me 5-Me N OMe Me 1-401 Me 5-CF₃ N OMe Me 1-402 CF₃ 5-Cl N OMe Me 1-403 CF₃ 5-Me N OMe Me 192-195 1-404 CF₃ 5-OMe N OMe Me 1-405 CF₃ 5-Cl N OMe Pr 1-406 CF₃ 5-Br N OMe Pr 1-407 CF₃ 5-Me N OMe Pr 149-152 1-408 CF₃ 5-Cl N OMe Pr-c 1-409 CF₃ 5-Br N OMe Pr-c 1-410 CF₃ 5-Me N OMe Pr-c 103-106 1-411 CF₃ 5-Cl N OEt Pr-c 1-412 CF₃ 5-Me N OEt Pr-c 1-413 CF₃ 5-CF₃ N OEt Pr-c 1-414 Me 5-Cl CH OEt Me 1-415 Me 5-Me CH OEt Me 1-416 Me 5-CF₃ CH OEt Me 1-417 Me 5-OMe CH OEt Me 1-418 CF₃ 5-Cl CH OEt Me 1-419 CF₃ 5-Me CH OEt Me 1-420 CF₃ 5-OMe CH OEt Me 136-139 1-421 Me 5-Cl N OEt Me 1-422 Me 5-Br N OEt Me

TABLE 49 m.p. Compound (° C.) or No. X Yn A R¹ R² RI (n_(D) ²⁰) 1-423 Me 5-Me N OEt Me 1-424 Me 5-CF₃ N OEt Me 1-425 CF₃ 5-Cl N OEt Me 1-426 CF₃ 5-Br N OEt Me 1-427 CF₃ 5-Me N OEt Me 1-428 CF₃ 5-Cl CH OCH₂CH═CH₂ Me 1-429 CF₃ 5-Me CH OCH₂CH═CH₂ Me 1-430 CF₃ 5-OMe CH OCH₂CH═CH₂ Me 1-431 CF₃ 5-Cl N OCH₂CH═CH₂ Me 1-432 CF₃ 5-Me N OCH₂CH═CH₂ Me 175-178 1-433 CF₃ 5-OMe N OCH₂CH═CH₂ Me 1-434 CF₃ 5-Me CH SMe Me 1-435 CF₃ 5-Cl CH SMe Me 1-436 CF₃ 5-Me N SMe Me 196-199 1-437 CF₃ 5-Cl N SMe Me 157-160 1-438 CF₃ 5-Cl N OMe Et 1-439 CF₃ 5-Br N OMe Et 1-440 CF₃ 5-Me N OMe Et 1-441 CF₃ 5-Cl N OEt Et 1-442 CF₃ 5-Br N OEt Et 1-443 CF₃ 5-Me N OEt Et 1-444 Me 5-Cl N SMe SMe 1-445 Me 5-Br N SMe SMe 1-446 Me 5-Me N SMe SMe 1-447 CF₃ 5-Cl N SMe SMe 1-448 CF₃ 5-Br N SMe SMe 1-449 CF₃ 5-Me N SMe SMe 1-450 Me 5-Cl N OMe SMe 1-451 Me 5-Br N OMe SMe 1-452 CF₃ 5-Cl N OMe SMe 1-453 CF₃ 5-Br N OMe SMe 1-454 CF₃ 5-Me N OMe SMe 1-455 Me 5-Me N OMe Ph

TABLE 50 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-456 CF₃ 5-Me N OMe Ph 219-222 1-457 Me H CH Cl Cl 1-458 Me 4,5-Cl₂ CH Cl Cl 1-459 Me H N Cl Cl 1-460 Me H CH Cl Me 1-461 Me 5-Cl N NMe₂ NMe₂ 1-462 CF₃ 5-Cl N NMe₂ NMe₂ 219-222 1-463 H H CH OMe NMe₂ 1-464 H H CBr OMe OMe 1-465 H H CMe Cl Cl 1-466 Me 5-Me COMe H H 1-467 Me 5-Cl COMe H H 1-468 Me 5-Cl CH Me Me 1-469 Me 5-CF₃ CH Me Me 1-470 Me 5-Cl CH Me CF₃ 1-471 Me 5-Me CH Me Et 1-472 Me 5-Cl CH Me Et 1-473 CF₃ 5-Me CH Me Et 1-474 CF₃ 5-Cl CH Me Et 1-475 Me 5-Me CH Me Pr-c 1-476 Me 5-Cl CH Me Pr-c 1-477 CF₃ 5-Me CH Me Pr-c 1-478 CF₃ 5-Cl CH Me Pr-c 1-479 CF₃ 5-Cl CH C≡CMe Me 1-480 CF₃ 5-Cl N C≡CMe Me 1-481 CF₃ 5-Cl CH CH═CH₂ Me 1-482 CF₃ 5-Cl N CH═CH₃ Me 1-483 Me 5-Cl CH CHO Me 1-484 Me 5-Cl N CHO Me 1-485 Me 5-Cl CH COMe Me 1-486 Me 5-Cl N COMe Me 1-487 Me 5-Cl CH CH₂OMe Me 1-488 Me 5-Me CH CH₂OMe Me

TABLE 51 m.p. (° C.) or Compound RI No. X Yn A R¹ R² (n_(D) ²⁰) 1-489 Me H CH CN CN 1-490 Me H CH CN Me 1-491 Me H N CN CN 1-492 Me H N CN Me 1-493 Me H CH SO₂Me SO₂Me 1-494 Me H N SO₂Me SO₂Me 1-495 Me H CH SO₂Me Me

TABLE 52

m.p. (° C.) Compound or RI No. Yn A R¹ R² (n_(D) ²⁰) 2-1 3-Me CH OMe OMe 2-2 3-Cl CH OMe OMe 2-3 4-F CH OMe OMe 194-196 2-4 4-Cl CH OMe OMe 188-190 2-5 4-Br CH OMe OMe 191-194 2-6 4-Me CH OMe OMe 158-161 2-7 4-Bu-t CH OMe OMe 2-8 4-CF₃ CH OMe OMe 178-180 2-9 4-OMe CH OMe OMe 189-190 2-10 4-OEt CH OMe OMe 178-180 2-11 4-OPr CH OMe OMe 2-12 4-OCF₃ CH OMe OMe 144-147 2-13 4-OCH₂CH═CH₂ CH OMe OMe 2-14 4-OCH₂C≡CH CH OMe OMe 2-15 4-OPh CH OMe OMe 2-16 4-OPh(4-Cl) CH OMe OMe 2-17 4-OPh(4-Me) CH OMe OMe 2-18 4-OPh(4-OMe) CH OMe OMe 2-19 4-SMe CH OMe OMe 2-20 4-CH₂OMe CH OMe OMe 2-21 4-COMe CH OMe OMe 2-22 4-COPh CH OMe OMe 2-23 4-CO₂Et CH OMe OMe 2-24 4-Ph CH OMe OMe

TABLE 53 m.p. (° C.) or Compound RI No. Yn A R¹ R² (n_(D) ²⁰) 2-25 4-Ph(4-Cl) CH OMe OMe 2-26 4-Ph(4-Me) CH OMe OMe 2-27 4-Ph(4-OMe) CH OMe OMe 2-28 4-NO₂ CH Ome OMe 2-29 4-NH₂ CH OMe OMe 2-30 4-NHMe CH OMe OMe 2-31 4-NMe₂ CH OMe OMe 2-32 4-CN CH OMe OMe 241-244 2-33 5-F CH OMe OMe 2-34 5-Cl CH OMe OMe 2-35 5-Me CH OMe OMe 2-36 5-CF₃ CH OMe OMe 2-37 5-OMe CH OMe OMe 2-38 5-CO₂Me CH OMe OMe 2-39 5-COPh CH OMe OMe 2-40 6-Me CH OMe OMe 136-139 2-41 6-Cl CH OMe OMe 2-42 4,5-Cl₂ CH OMe OMe 2-43 4,5-Me₂ CH OMe OMe 2-44 4,5-(OMe)₂ CH OMe OMe 2-45 4,6-Me₂ CH OMe OMe 139-142 2-46 3-Br, 5-CF₃ CH OMe OMe 2-47 3-Cl, 5-CF₃ CH OMe OMe 2-48 3,4,5-F₃ CH OMe OMe 2-49 H N OMe OMe 177-180 2-50 3-Me N OMe OMe 2-51 3-Cl N OMe OMe 2-52 4-F N OMe OMe 184-187 2-53 4-Cl N OMe OMe 206-208 2-54 4-Br N OMe OMe 2-55 4-I N OMe OMe 218-221

TABLE 54 Compound m.p. (° C.) No. Yn A R¹ R² or RI (n_(D) ²⁰) 2-56 4-Me N OMe OMe 189-191 2-57 4-Et N OMe OMe 146-149 2-58 4-Pr N OMe OMe 170-173 2-59 4-CF₃ N OMe OMe 2-60 4-Bu-t N OMe OMe 118-121 2-61 4-C≡CBu-t N OMe OMe 117-120 2-62 4-OMe N OMe OMe 197-199 2-63 4-OEt N OMe OMe 2-64 4-OPr N OMe OMe 2-65 4-OCF₃ N OMe OMe 119-122 2-66 4-OCH₂CH═CH₂ N OMe OMe 2-67 4-OCH₂C≡CH N OMe OMe 2-68 4-OPh N OMe OMe 2-69 4-SMe N OMe OMe 2-70 4-COPh N OMe OMe 221-224 2-71 4-CO₂Me N OMe OMe 289-292 2-72 4-Ph N OMe OMe 2-73 4-Ph(4-Cl) N OMe OMe 2-74 4-Ph(4-Me) N OMe OMe 2-75 4-Ph(4-OMe) N OMe OMe 2-76 4-NO₂ N OMe OMe 2-77 4-NH₂ N OMe OMe 2-78 4-NHMe N OMe OMe 2-79 4-NMe₂ N OMe OMe 155-158 2-80 4-CN N OMe OMe 189-201 2-81 5-F N OMe OMe 2-82 5-Cl N OMe OMe 2-83 5-Me N OMe OMe 151-154 2-84 5-CF₃ N OMe OMe 2-85 5-OMe N OMe OMe 2-86 5-NO₂ N OMe OMe

TABLE 55 m.p. (° C.) or Compound RI No. Yn A R¹ R² (n_(D) ²⁰) 2-87 5-CO₂Et N OMe OMe 2-88 5-COPh N OMe OMe 2-89 6-Me N OMe OMe 2-90 6-Cl N OMe OMe 2-91 4,5-Cl₂ N OMe OMe 2-92 4,5-Me₂ N OMe OMe 2-93 4,5-(OMe)₂ N OMe OMe 2-94 3-Br,5-CF₃ N OMe OMe 2-95 3-Cl,5-CF₃ N OMe OMe 2-96 3,4,5-F₃ N OMe OMe 2-97 4-Me N OMe OEt 173-175 2-98 4-Cl N OMe OEt 130-132 2-99 4-Br N OMe OEt 2-100 H CH OEt OEt 92-95 2-101 4-F CH OEt OEt 131-134 2-102 4-Cl CH OEt OEt 147-149 2-103 4-Br CH OEt OEt 2-104 4-Me CH OEt OEt 147-150 2-105 4-CF₃ CH OEt OEt 134-137 2-106 4-F N OEt OEt 2-107 4-Cl N OEt OEt 2-108 4-Br N OEt OEt 2-109 4-Me N OEt OEt 2-110 4-CF₃ N OEt OEt 2-111 4-Cl N OPr OPr 2-112 4-Cl CH OPr-i OPr-i 2-113 4-Me CH OPr-i OPr-i 2-114 4-Cl N OPr-i OPr-i 2-115 4-Br N OPr-i OPr-i 2-116 4-Cl N OCH₂CH═CH₂ OCH₂CH═CH₂ 2-117 4-Br N OCH₂CH═CH₂ OCH₂CH═CH₂

TABLE 56 m.p. (° C.) Com- or pound RI No. Yn A R¹ R² (n_(D) ²⁰) 2-118 4-Cl N OCH₂C≡CH OCH₂C≡CH 2-119 4-Br N OCH₂C≡CH OCH₂C≡CH 2-120 4-Cl N OCH₂CN OCH₂CN 2-121 4-Br N OCH₂CN OCH₂CN 2-122 4-Br N OCH₂CH₂OMe OCH₂CH₂OMe 2-123 4-Cl N OCH₂CH₂OMe OCH₂CH₂OMe 2-124 4-Br N OCH₂Pr-c OCH₂Pr-c 2-125 4-Cl N OCH₂Pr-c OCH₂Pr-c 65-68 2-126 H CH OBn OBn 2-127 H N OBn OBn 2-128 H N OBn(4-Cl) OBn(4-Cl) 2-129 H N OBn(4-Me) OBn(4-Me) 2-130 H N OBn(4-OMe) OBn(4-OMe) 2-131 H CH OMe OPh 2-132 H N OMe OPh 2-133 H N OMe OPh(4-Cl) 2-134 H N OMe OPh(4-Me) 2-135 H N OMe OPh(4-OMe) 2-136 H CH OMe OCHF₂ 2-137 H N OMe OCHF₂ 2-138 4-Cl CH OMe H 136-139 2-139 4-Me CH OMe H 136-139 2-140 4-Cl CH OEt H 118-119 2-141 4-Me CH OEt H  99-100 2-142 4-Cl CH OMe Me 2-143 4-Me CH OMe Me 2-144 4-CF₃ CH OMe Me 155-158 2-145 4-Cl N OMe Me 2-146 4-Me N OMe Me 2-147 4-Cl N OMe Pr 2-148 4-Me N OMe Pr 116-119

TABLE 57 m.p. (° C.) or Compound RI No. Yn A R¹ R² (n_(D) ²⁰) 2-149 4-Cl N OMe Pr-c 2-150 4-Br N OMe Pr-c 2-151 4-Me N OMe Pr-c 130133 2-152 4-Cl N OEt Pr-c 2-153 4-Me N OEt Pr-c 2-154 4-Cl N OMe Et 109-112 2-155 4-Br N OMe Et 113-116 2-156 4-Me N OMe Et 2-157 4-Cl N OEt Et 2-158 4-Br N OEt Et 2-159 4-Me N OEt Et 2-160 4-Me N OPr Me 175-178 2-161 4-Cl N OPr Me 2-162 4-Me CH Me Et 75-78 2-163 4-Cl CH Me Et 2-164 4-Me CH Et Et 64-67 2-165 4-Cl CH Et Et 2-166 4-Me N Me SMe 174-177 2-167 4-Cl N SMe SMe 179-182 2-168 4-Br N SMe SMe 2-169 4-Me N SMe SMe 2-170 4-Cl N OMe SMe 2-171 4-Me N OMe SMe 2-172 4-Me N OMe Ph 165-168 2-173 4-Cl N NMe₂ NMe₂  >300 2-174 H CBr OMe OMe 2-175 H CMe Cl Cl 2-176 4-Me COMe H H 2-177 4-Cl COMe H H 2-178 4-Me N Cl Ph 106-109 2-179 4-Cl N Cl Ph

TABLE 58 m.p. (° C.) or Compound RI No. Yn A R¹ R² (n_(D) ²⁰) 2-180 4-Cl CH C≡CMe Me 2-181 4-Cl N C≡CMe Me 2-182 4-Cl CH CH═CH₂ Me 2-183 4-Cl N CH═CH₂ Me 2-184 4-Cl CH CHO Me 2-185 4-Cl N CHO Me 2-186 4-Cl CH COMe Me 2-187 4-Cl N COMe Me 2-188 4-Cl CH CH₂OMe Me 2-189 4-Me CH CH₂OMe Me 2-190 H CH CN CN 2-191 H CH CN Me 2-192 H N CN CN 2-193 H N CN Me 2-194 H CH SO₂Me SO₂Me 2-195 H N SO₂Me SO₂Me 2-196 H CH SO₂Me Me

TABLE 59

m.p. (° C.) Compound or RI No. Yn A R¹ R² (n_(D) ²⁰) 3-1 3-Me CH OMe OMe 3-2 3-Cl CH OMe OMe 3-3 4-F CH OMe OMe 120-123 3-4 4-Cl CH OMe OMe 3-5 4-Br CH OMe OMe 117-118 3-6 4-Me CH OMe OMe 128-129 3-7 4-Bu-t CH OMe OMe 3-8 4-CF₃ CH OMe OMe 113-115 3-9 4-OMe CH OMe OMe 3-10 4-OEt CH OMe OMe 129-132 3-11 4-OPr CH OMe OMe 3-12 4-OCF₃ CH OMe OMe 85-88 3-13 4-OCH₂CH═CH₂ CH OMe OMe 3-14 4-OCH₂C≡CH CH OMe OMe 3-15 4-OPh CH OMe OMe 3-16 4-OPh(4-Cl) CH OMe OMe 3-17 4-OPh(4-Me) CH OMe OMe 3-18 4-OPh(4-OMe) CH OMe OMe 3-19 4-SMe CH OMe OMe 3-20 4-CH₂OMe CH OMe OMe 3-21 4-COMe CH OMe OMe 3-22 4-COPh CH OMe OMe 3-23 4-CO₂Et CH OMe OMe 3-24 4-Ph CH OMe OMe 130-132

TABLE 60 m.p. (° C.) or Compound RI No. Yn A R¹ R² (n_(D) ²⁰) 3-25 4-Ph(4-Cl) CH OMe OMe 3-26 4-Ph(4-Me) CH OMe OMe 3-27 4-Ph(4-OMe) CH OMe OMe 3-28 4-NO₂ CH OMe OMe 3-29 4-NH₂ CH OMe OMe 3-30 4-NHMe CH OMe OMe 3-31 4-NMe₂ CH OMe OMe 3-32 4-CN CH OMe OMe 166-169 3-33 5-F CH OMe OMe 3-34 5-Cl CH OMe OMe 124-125 3-35 5-Me CH OMe OMe 91-94 3-36 5-CF₃ CH OMe OMe 3-37 5-OMe CH OMe OMe 3-38 5-CO₂Me CH OMe OMe 3-39 5-COPh CH OMe OMe 3-40 6-Me CH OMe OMe 3-41 6-Cl CH OMe OMe 3-42 4,5-Cl₂ CH OMe OMe 3-43 4,6-Me₂ CH OMe OMe 145-147 3-44 4,5-Me₂ CH OMe OMe 3-45 4,5-(OMe)₂ CH OMe OMe 3-46 3-Br,5-CF₃ CH OMe OMe 3-47 3-Cl,5-CF₃ CH OMe OMe 3-48 3,4,5-F₃ CH OMe OMe 3-49 H N OMe OMe 152-155 3-50 3-Me N OMe OMe 3-51 3-Cl N OMe OMe 3-52 4-F N OMe OMe 183-186 3-53 4-Cl N OMe OMe 202-205 3-54 4-Br N OMe OMe 200-203 3-55 4-I N OMe OMe 191-194

TABLE 61 m.p. (° C.) or Compound RI No. Yn A R¹ R² (n_(D) ²⁰) 3-56 4-Me N OMe OMe 180-183 3-57 4-Et N OMe OMe 123-126 3-58 4-Pr N OMe OMe 136-139 3-59 4-CF₃ N OMe OMe 177-180 3-60 4-Bu-t N OMe OMe 140-143 3-61 4-C≡CBu-t N OMe OMe 161-164 3-62 4-OMe N OMe OMe 182-185 3-63 4-OEt N OMe OMe 3-64 4-OPr N OMe OMe 3-65 4-OCF₃ N OMe OMe 3-66 4-OCH₂CH═CH₂ N OMe OMe 3-67 4-OCH₂C≡CH N OMe OMe 3-68 4-OPh N OMe OMe 3-69 4-SMe N OMe OMe 3-70 4-COPh N OMe OMe 175-178 3-71 4-CO₂Me N OMe OMe 197-200 3-72 4-Ph N OMe OMe 3-73 4-Ph(4-Cl) N OMe OMe 3-74 4-Ph(4-Me) N OMe OMe 3-75 4-Ph(4-OMe) N OMe OMe 3-76 4-NO₂ N OMe OMe 3-77 4-NH₂ N OMe OMe 3-78 4-NHMe N OMe OMe 3-79 4-NMe₂ N OMe OMe 115-118 3-80 4-CN N OMe OMe 215-218 3-81 5-F N OMe OMe 3-82 5-Cl N OMe OMe 3-83 5-Me N OMe OMe 131-134 3-84 5-CF₃ N OMe OMe 3-85 5-OMe N OMe OMe 3-86 5-NO₂ N OMe OMe

TABLE 62 m.p. (° C.) or Compound RI No. Yn A R¹ R² (n_(D) ²⁰) 3-87 5-CO₂Et N OMe OMe 3-88 5-COPh N OMe OMe 3-89 6-Me N OMe OMe 3-90 6-Cl N OMe OMe 3-91 4,5-Cl₂ N OMe OMe 3-92 4,5-Me₂ N OMe OMe 3-93 4,5-(OMe)₂ N OMe OMe 3-94 3-Br,5-CF₃ N OMe OMe 3-95 3-Cl,5-CF₃ N OMe OMe 3-96 3,4,5-F₃ N OMe OMe 3-97 4-Me N OMe OEt 134-137 3-98 4-Cl N OMe OEt 132-135 3-99 4-Br N OMe OEt 140-142 3-100 H CH OEt OEt 146-148 3-101 4-F CH OEt OEt 3-102 4-Cl CH OEt OEt 3-103 4-Br CH OEt OEt 3-104 4-Me CH OEt OEt 3-105 4-CF₃ CH OEt OEt 167-170 3-106 4-F N OEt OEt 3-107 4-Cl N OEt OEt 163-166 3-108 4-Br N OEt OEt 172-175 3-109 4-Me N OEt OEt 158-161 3-110 4-Bu-t N OEt OEt 128-129 3-111 4-OMe N OEt OEt 128-129 3-112 4-CF₃ N OEt OEt 3-113 4-Cl N OPr OPr 145-148 3-114 4-Cl CH OPr-i OPr-i 3-115 4-Me CH OPr-i OPr-i 3-116 4-Cl N OPr-i OPr-i 179-182 3-117 4-Br N OPr-i OPr-i

TABLE 63 m.p. (° C.) Com- or pound RI No. Yn A R¹ R² (n_(D) ²⁰) 3-118 4-Cl N OCH₂CH═CH₂ OCH₂CH═CH₂ 3-119 4-Br N OCH₂CH═CH₂ OCH₂CH═CH₂ 3-120 4-Cl N OCH₂C≡CH OCH₂C≡CH 3-121 4-Br N OCH₂C≡CH OCH₂C≡CH 3-122 4-Cl N OCH₂CN OCH₂CN 3-123 4-Br N OCH₂CN OCH₂CN 3-124 4-Br N OCH₂CH₂OMe OCH₂CH₂OMe 3-125 4-Cl N OCH₂CH₂OMe OCH₂CH₂OMe 3-126 4-Br N OCH₂Pr-c OCH₂Pr-c 3-127 4-Cl N OCH₂Pr-c OCH₂Pr-c 156-159 3-128 H CH OBn OBn 3-129 H N OBn OBn 3-130 H N OBn(4-Cl) OBn(4-Cl) 3-131 H N OBn(4-Me) OBn(4-Me) 3-132 H N OBn(4-OMe) OBn(4-OMe) 3-133 H CH OMe OPh 3-134 H N OMe OPh 3-135 H N OMe OPh(4-Cl) 3-136 H N OMe OPh(4-Me) 3-137 H N OMe OPh(4-OMe) 3-138 H CH OMe OCHF₂ 3-139 H N OMe OCHF₂ 3-140 4-Cl CH OMe H 136-139 3-141 4-Me CH OMe H 126-129 3-142 4-Cl CH OEt H 113-115 3-143 4-Me CH OEt H 103-105 3-144 4-Cl CH OMe Me 3-145 4-Me CH OMe Me 3-146 4-CF₃ CH OMe Me 134-137 3-147 4-Cl N OMe Me 3-148 4-Me N OMe Me 202-205

TABLE 64 m.p. (° C.) or Compound RI No. Yn A R¹ R² (n_(D) ²⁰) 3-149 4-Cl N OMe Pr 3-150 4-Me N OMe Pr 133-136 3-151 4-Cl N OMe Pr-c 3-152 4-Br N OMe Pr-c 163-165 3-153 4-Me N OMe Pr-c 56-59 3-154 4-Cl N OEt Pr-c 163-166 3-155 4-Me N OEt Pr-c 105-108 3-156 4-Cl N OMe Et 155-158 3-157 4-Br N OMe Et 162-165 3-158 4-Me N OMe Et 171-174 3-159 4-Cl N OEt Et 3-160 4-Br N OEt Et 3-161 4-Me N OEt Et 3-162 4-Me N OPr Me 3-163 4-Cl N OPr Me 3-164 4-Me CH Me Et 92-95 3-165 4-Cl CH Me Et 3-166 4-Me CH Et Et 91-94 3-167 4-Cl CH Et Et 3-168 4-Me N Me SMe 180-183 3-169 4-Cl N SMe SMe 192-195 3-170 4-Br N SMe SMe 3-171 4-Me N SMe SMe 3-172 4-Cl N OMe SMe 3-173 4-Me N OMe SMe 3-174 4-Me N OMe Ph 170-173 3-175 4-Cl N NMe₂ NMe₂ 176-179 3-176 H CBr OMe OMe 3-177 H CMe Cl Cl 3-178 4-Me COMe H H 3-179 4-Cl COMe H H

TABLE 65 m.p. (° C.) or Compound RI No. Yn A R¹ R² (n_(D) ²⁰) 3-180 4-Me N Cl Ph 3-181 4-Cl N Cl Ph 3-182 4-Cl CH C≡CMe Me 3-183 4-Cl N C≡CMe Me 3-184 4-Cl CH CH═CH₂ Me 3-185 4-Cl N CH═CH₂ Me 3-186 4-Cl CH CHO Me 3-187 4-Cl N CHO Me 3-188 4-Cl CH COMe Me 3-189 4-Cl N COMe Me 3-190 4-Cl CH CH₂OMe Me 3-191 4-Me CH CH₂OMe Me 3-192 H CH CN CN 3-193 H CH CN Me 3-194 H N CN CN 3-195 H N CN Me 3-196 H CH SO₂Me SO₂Me 3-197 H N SO₂Me SO₂Me 3-198 H CH SO₂Me Me

BEST MODE FOR CARRYING OUT THE INVENTION

Now, the processes for producing the compound of the present invention, formulation methods and applications will be specifically described with reference to Examples.

PREPARATION EXAMPLE 1 1-(4-methoxypyrimidin-2-yl)-benzimidazole (Compound Number I-667)

Benzimidazole (0.50 g) was dissolved in dimethylformamide (10 ml), and sodium hydride (60% purity, oily) (0.18 g) was added thereto at room temperature. After stirring for 1 hour, 2-chloro-4-methoxypyrimidine (0.62 g) was added at room temperature, followed by stirring for 3 hours. Ice water was added, followed by extraction with ethyl acetate, washing with a saturated sodium chloride aqueous solution and drying over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 0.40 g of the desired product as a white powder (m.p. 114-116° C.).

PREPARATION EXAMPLE 2 1-(4,6-dimethoxypyrimidin-2-yl)-2-methylthiobenzimidazole (Compound Number I-4)

2-Methylthiobenzimidazole (0.50 g) was dissolved in dimethylformamide (10 ml), and sodium hydride (60% purity, oily) (0.13 g) was added thereto at room temperature. After stirring for 1 hour, 2-methylsulfonyl-4,6-dimethoxypyrimidine (0.67 g) was added at room temperature, followed by stirring for 8 hours. Ice water was added, followed by extraction with ethyl acetate, washing with a saturated sodium chloride aqueous solution and drying over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 0.80 g of the desired product as a white powder (m.p. 135-137° C.).

PREPARATION EXAMPLE 3 1-(4,6-dimethoxypyrimidin-2-yl)-2-methylsulfonylbenzimidazole (Compound Number I-5)

1-(4,6-dimethoxypyrimidin-2-yl)-2-methylthiobenzimidazole (0.70 g) and m-chloroperbenzoic acid (1.30 g) were dissolved in chloroform (30 ml), followed by stirring at room temperature for 3 hours. The reaction liquid was washed with a 5% aqueous potassium carbonate solution and water, and the organic solvent layer was dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 0.50 g of the desired product as a white powder (m.p. 114-117° C.).

PREPARATION EXAMPLE 4 1-(4,6-dimethoxypyrimidin-2-yl)-2-methoxybenzimidazole (Compound Number I-18)

1-(4,6-dimethoxypyrimidin-2-yl)-2-methylsulfonylbenzimidazole (0.40 g) was dissolved in tetrahydrofuran (20 ml), and sodium methylate (0.50 g) was added thereto under cooling with ice, followed by stirring for 1 hour. Ice water was added, followed by extraction with ethyl acetate, washing with a saturated sodium chloride aqueous solution and drying over anhydrous magnesium sulfate. The solvent was distilled off, and the mixture was purified by silica gel column chromatography to obtain 0.40 g of the desired product as a white powder (m.p. 121-122° C.).

PREPARATION EXAMPLE 5 1-(4,6-dimethoxypyrimidin-2-yl)-2,5-dimethylbenzimidazole (Compound Number I-186)

N′-(4,6-dimethoxypyrimidin-2-yl)-4-methylbenzene-1,2-diamine (2.50 g) was dissolved in acetic acid (20 ml) and acetic anhydride (10 ml), followed by reflux for 4 hours. Water was added, and the crystals were collected by filtration, washed with water and dried. Recrystallization from ethanol was carried out to obtain 1.90 g of the desired product as white feather-like crystals (m.p. 163-166° C.).

PREPARATION EXAMPLE 6 2-amino-1-(4,6-dimethoxypyrimidin-2-yl)-5-methylbenzimidazole (Compound Number I-362)

N′-(4,6-dimethoxypyrimidin-2-yl)-4-methylbenzene-1,2-diamine (2.00 g) was dissolved in ethanol, and cyanogen bromide (1.00 g) was added thereto at room temperature, followed by stirring at 60° C. for 1 hour. Water was added, and the crystals were collected by filtration, washed with water and dried to obtain 2.03 g of the desired product as a white powder (m.p. at least 300° C.)

PREPARATION EXAMPLE 7 2-chloro-1-(4,6-dimethoxypyrimidin-2-yl)-5-methylbenzimidazole (Compound Number I-258)

2-Amino-1-(4,6-dimethoxypyrimidin-2-yl)-5-methylbenzimidazole (1.67 g) and copper(II)chloride (0.94 g) were suspended in acetonitrile (30 ml), and tert-butyl nitrite (0.90 g) was added thereto at room temperature, followed by reflux for 30 minutes. Water was added, followed by extraction with ethyl acetate, washing with a saturated sodium chloride aqueous solution and drying over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 1.48 g of the desired product as white feather-like crystals (m.p. 145-148° C.).

PREPARATION EXAMPLE 8 1-(4,6-dimethoxypyrimidin-2-yl)-5-methyl-2-trifluoromethylbenzimidazole (Compound Number I-298)

2-(4,6-dimethoxypyrimidin-2-yl)amino-5-methyltrifluoroacetic anilide (0.60 g) and para-toluenesulfonic acid (0.05 g) were dissolved in toluene (30 ml), followed by reflux for 5 hours. Water and ethyl acetate were added, and the organic layer was washed with a saturated sodium hydrogencarbonate solution and a saturated sodium chloride aqueous solution and dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 0.56 g of the desired product as a white powder (m.p. 93-96° C.).

PREPARATION EXAMPLE 9 1-(4,6-dichloro-[1,3,5]triazin-2-yl)-2-methylbenzimidazole (Compound Number I-1066)

2-Methylbenzimidazole (5.0 g) was dissolved in tetrahydrofuran (50 ml), and sodium hydride (60% purity, oily) (1.6 g) was added thereto at room temperature. After stirring for 1 hour, cyanuric chloride (7.0 g) was added at room temperature, followed by stirring for 3 hours. Ice water was added, followed by extraction with ethyl acetate, washing with a saturated sodium chloride aqueous solution and drying over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 2.6 g of the desired product as a white powder (m.p. at least 300° C.)

PREPARATION EXAMPLE 10 1-(4,6-dimethylthio-[1,3,5]triazin-2-yl)-2-methylbenzimidazole (Compound Number I-1042)

1-(4,6-dichloro-[1,3,5]triazin-2)-2-methylbenzimidazole (0.5 g) was dissolved in methanol (10 ml), and a 15% aqueous methyl mercaptan sodium salt solution (0.25 g) was added at room temperature, followed by stirring for 1 hour. After the completion of the reaction, the reaction liquid was poured into ice water, and the crystals thus deposited were collected by filtration, washed with water and dried to obtain 0.46 g of the desired product as a white powder (m.p. 176-179° C.)

PREPARATION EXAMPLE 11 5-chloro-1-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-2-methylbenzimidazole (Compound Number I-215)

4-Chloro-N′-(4,6-dimethoxy-[1,3,5]triazin-z-2-yl)benzene-1,2-diamine (0.5 g) was dissolved in acetic acid (10 ml), and acetic anhydride (10 ml) followed by reflux for 4 hours. Water was added, and the crystals were collected by filtration, washed with water and dried. Recrystallization from ethanol was carried out to obtain 0.47 g of the desired product as white feather-like crystals (m.p. 173-176° C.)

PREPARATION EXAMPLE 12 5-chloro-1-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-2-methylbenzimidazole (Compound Number I-215)

2-Nitro-4-chloro-N-(4,6-dimethoxy-[1,3,5]triazin-2-yl)aniline (0.5 g) and iron powder (0.3 g) were dissolved in acetic acid (10 ml) and acetic anhydride (5 ml), followed by reflux for 4 hours. The reaction mixture was cooled to room temperature, followed by filtration. The filtrate was concentrated under reduced pressure, water was added to the residue, and the crystals were collected by filtration, washed with water and dried. Recrystallization from ethanol was carried out to obtain 0.39 g of the desired product as white feather-like crystals (m.p. 173-176° C.)

PREPARATION EXAMPLE 13 2-amino-5-chloro-1-(4,6-dimethoxy-[1,3,5]triazin-2-yl)benzimidazole (Compound Number I-368)

4-Chloro-N′-(4,6-dimethoxy-[1,3,5]triazin-2-yl)benzene-1,2-diamine (1.5 g) was dissolved in ethanol (50 ml), and cyanogen bromide (0.6 g) was added thereto at room temperature, followed by stirring at 60° C. for 1 hour. Water was added, and the crystals were collected by filtration, washed with water and dried to obtain 1.2 g of the desired product as a pink powder (m.p. 293-296° C.)

PREPARATION EXAMPLE 14 2,5-dichloro-1-(4,6-dimethoxy-[1,3,5]triazin-2-yl)benzimidazole (Compound Number I-277)

2-Amino-5-chloro-1-(4,6-dimethoxy-[1,3,5]triazin-2-yl)benzimidazole (1.1 g) and copper(II)chloride (0.6 g) were suspended in acetonitrile (50 ml), and tert-butyl nitrite (0.5 g) was added thereto at room temperature, followed by reflux for 30 minutes. Water was added, followed by extraction with ethyl acetate, washing with a saturated sodium chloride aqueous solution and drying over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 0.5 g of the desired product as white feather-like crystals (m.p. 146-149° C.).

PREPARATION EXAMPLE 15 1-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-5-methyl-2-trifluoromethylbenzimidazole (Compound Number I-312)

2-(4,6-dimethoxy-[1,3,5]triazin-2-yl)amino-5-methyltrifluoroacetic anilide (1.0 g) and para-toluenesulfonic acid (0.05 g) were dissolved in chlorobenzene (30 ml), followed by reflux for 5 hours. Water and ethyl acetate were added, and the organic layer was washed with a saturated sodium hydrogencarbonate solution and a saturated sodium chloride aqueous solution and dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 0.23 g of the desired product as a white powder (m.p. 137-140° C.).

Now, ¹H-NMR (CDCl₃/TMS, δ (ppm)) data of some among examples of the compounds of the present invention, will be shown below.

TABLE 66 Compound No. ¹H-NMR δ(ppm), solvent CDCl₃ I-30 2.99(6H, s); 4.03(6H, s); 5.99(1H, s); 7.03-7.09(1H, m); 7.17-7.22(1H, m); 7.48-7.51(1H, m); 7.84-7.85(1H, m); 8.01(1H, s) I-34 3.64(6H, s); 5.92(1H, s); 7.42-7.36(5H, m); 7.56-7.60(2H, m); 7.58-7.88(1H, m); 8.20-8.23(1H, m) I-840 1.41(6H, d, J=6.3Hz); 2.52(3H, s); 2.98(3H, s); 5.39-5.47(1H, m); 6.46(1H, s); 7.26-7.33(2H, m); 7.69-7.72(1H, m); 8.25-8.28(1H, m) I-872 1.01(3H, t, J=7.5Hz); 1.49-1.57(2H, m); 1.80-1.87(2H, m); 2.51(3H, s); 4.50(2H, t, J=6.57Hz); 6.45(1H, s); 7.33-7.43(2H, m); 7.82-7.85(1H, m); 8.55-8.59(1H, m); 9.05(1H, s) I-906 1.66-2.11(8H, m); 2.45(3H, s); 5.51-5.56(1H, m); 6.36(1H, s); 7.28-7.41(2H, m); 7.81-7.83(1H, m); 8.45-8.52(1H, m); 9.05(1H, s) I-907 1.65-2.04(8H, m); 2.51(3H, s); 3.98(3H, s); 5.51-5.55(1H, m); 6.46(1H, s); 7.26-7.34(2H, m); 7.68-7.73(1H, m); 8.25-8.31(1H, m) I-959 1.03(3H, t, J=7.41Hz); 1.81-1.89(2H, m); 2.76(2H, t, J=7.14Hz); 3.00(3H, s); 4.08(3H, s); 6.51(1H, s); 7.27-7.33(2H, m); 7.70-7.73(1H, m); 8.28-8.34(1H, m) I-960 1.03(3H, t, J=7.29Hz); 1.81-1.89(2H, m); 2.77(2H, t, J=7.29Hz); 4.07(3H, s); 6.58(1H, s); 7.30-7.37(2H, m); 7.71-7.74(1H, m); 8.00-8.05(1H, m)

Now, Preparation Examples of intermediates for the synthesis of the compounds of the present invention will be shown below.

PREPARATION EXAMPLE 16 N-(4,6-dimethoxypyrimidin-2-yl)-4-methyl-2-nitroaniline (Compound Number 2-6)

N-formyl-4-methyl-2-nitroaniline (25.00 g) was dissolved in dimethylformamide (400 ml), and sodium hydride (60% purity, oily) (6.11 g) was added thereto at room temperature. After stirring for 10 minutes, 2-methylsulfonyl-4,6-dimethoxypyrimidine (30.28 g) was added at room temperature, followed by stirring for 3 hours. A 10% NaOH aqueous solution was added thereto, and the crystals were collected by filtration, washed with water and dried to obtain 37.50 g of the desired product as a yellow powder (m.p. 158-161° C.).

PREPARATION EXAMPLE 17 N′-(4,6-dimethoxypyrimidin-2-yl)-4-methylbenzene-1,2-diamine (Compound Number 3-6)

N-(4,6-dimethoxypyrimidin-2-yl)-4-methyl-2-nitroaniline (37.50 g) was dissolved in ethyl acetate (600 ml), and 10% palladium carbon (3.75 g) was added thereto. Stirring was carried out at room temperature under normal pressure in an atmosphere of hydrogen for 4 hours, followed by filtration. The solvent of the filtrate was distilled off to obtain 32.70 g of the desired product as a white powder (m.p. 128-129° C.)

PREPARATION EXAMPLE 18 2-(4,6-dimethoxypyrimidin-2-yl)amino-5-methyltrifluoroacetic anilide (Compound Number 1-196)

N′-(4,6-dimethoxypyrimidin-2-yl)-4-methylbenzene-1,2-diamine (0.80 g) was dissolved in pyridine (10 ml), and trifluoroacetic anhydride (0.97 g) was added thereto under cooling with ice salt. After stirring for 1 hour, diluted hydrochloric acid was added thereto, followed by extraction with ethyl acetate, washing with diluted hydrochloric acid and a saturated sodium chloride aqueous solution and drying over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 0.88 g of the desired product as a white powder (m.p. 144-147° C.).

PREPARATION EXAMPLE 19 N-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-4-methyl-2-nitroaniline (Compound Number 2-56)

N-formyl-4-methyl-2-nitroaniline (7.2 g) was dissolved in tetrahydrofuran (50 ml), and sodium hydride (60% purity, oily) (2.0 g) was added thereto at room temperature. After stirring for 10 minutes, 2-chloro-4,6-dimethoxy-[1,3,5]triazine (7.0 g) was added at room temperature, followed by stirring for 3 hours. A 10% aqueous sodium hydroxide solution was added thereto, and the crystals were collected by filtration, washed with water and dried to obtain 10.0 g of the desired product as a yellow powder (m.p. 189-191° C.)

SYNTHESIS EXAMPLE 20 N′-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-4-methylbenzene-1,2-diamine (Compound Number 3-56)

N-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-4-methyl-2-nitroaniline (10 g) was dissolved in ethyl acetate (50 ml) and water (50 ml), and 10 g of iron power and acetic acid (2 ml) were added thereto, followed by reflux for 2 hours. Insoluble matters were removed by filtration, and the ethyl acetate layer was washed with a saturated sodium chloride aqueous solution and dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain 8.8 g of the desired product as a white powder (m.p. 180-183° C.).

PREPARATION EXAMPLE 21 2-(4,6-dimethoxy-[1,3,5]triazin-2-yl)amino-5-methyltrifluoroacetic anilide (Compound Number 1-210)

N′-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-4-methylbenzene-1,2-diamine (1.0 g) was dissolved in pyridine (50 ml), and trifluoroacetic anhydride (0.8 g) was added thereto under cooling with ice salt. After stirring for 1 hour, diluted hydrochloric acid was added thereto, followed by extraction with ethyl acetate, washing with diluted hydrochloric acid and a saturated sodium chloride aqueous solution and drying over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 1.3 g of the desired product as a white powder (m.p. 195-198° C.).

PREPARATION EXAMPLE 22 4-chloro-N-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-2-nitroaniline (Compound Number 2-53)

4-Chloro-2-nitroaniline (5.0 g) and sodium hydrogencarbonate (3.6 g) were dissolved in tetrahydrofuran (50 ml), and cyanuric chloride (8.0 g) was added thereto, followed by stirring for 8 hours. To the reaction solution, 28% sodium methylate (11.2 g) was added, followed by reflux for 1 hour. Water was added thereto, followed by extraction with ethyl acetate, washing with a saturated sodium chloride aqueous solution and drying over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was subjected to recrystallization from ethanol to obtain 6.3 of the desired product as a yellow powder (m.p. 206-208° C.).

The agricultural/horticultural fungicides of the present invention contain triazinylbenzimidazole derivatives represented by the general formula [I] as the active ingredients. When the compounds of the present invention are used for agricultural/horticultural fungicides, the active ingredient can be used in appropriate formulations depending on the purpose. The active ingredient is usually diluted with an inert liquid or solid carrier and is used in an appropriate dosage form such as a dust, a wettable powder, an emulsifiable concentrate or a granule by blending it with a surfactant and other ingredients, depending on its use.

Preferable examples of carriers include solid carriers such as talc, bentonite, clay, kaolin, diatomaceous earth, white carbon, vermiculite, slaked lime, silica sand, ammonium sulfate and urea and liquid carriers such as isopropyl alcohol, xylene, cyclohexanone and methylnaphthalene. Examples of surfactants and dispersants include dinaphthylmethanesulfonates, alcohol-sulfuric acid ester salts, alkylarylsulfonates, lignin sulfonate, polyoxyethylene glycol ether, polyoxyethylene alkyl aryl ethers and polyoxyethylene sorbitan monoalkylate. Examples of adjuvants include carboxymethyl cellulose and the like. These formulations are applied after diluted to appropriate concentrations or directly.

The agricultural/horticultural fungicides of the present invention can be used for foliage treatment, soil treatment or submerged treatment. The blending proportion of the active ingredient is suitably selected depending on the case. However, the preferable proportion is from 0.1 to 20% (by weight) in the cases of a dust or a granule, and from 5 to 80% (by weight) in the cases of an emulsifiable concentrate or a wettable powder.

The dose of the agricultural/horticultural fungicides of the present invention depends on the type of the compound to be used, the disease to be controlled, the tendency of disease development, the degrees of the damage, the environmental conditions and the type of the formulation to be used. For example, for direct use as a dust or a granule, the dose of the active ingredient is selected suitably within a range of from 0.1 g to 5 kg, preferably from 1 g to 1 kg, per 10 are. For use in a liquid state as an emulsifiable concentrate or a wettable powder, the dose is selected suitably within a range of from 0.1 ppm to 10,000 ppm, preferably from 1 to 3,000 ppm.

The compounds of the present invention in the above formulations can control plant diseases caused by Oomycetes, Ascomycetes, Deuteromycetes and Basidiomycetes. Specific but non-restrictive examples of microorganisms are given below. Pseudoperonospora genus such as Pseudoperonospora cubensis, Erysiphe genus such as Erysiphe graminis, Venturia genus such as Venturia inaequalis, Pyricularia genus such as Pyricularia oryzae, Botrytis genus such as Botrytis cinerea, Rhizoctonia genus such as Rhizoctonia solani and Puccinia genus such as Puccinia recondita.

The compounds of the present invention can be used in combination with insecticides, other fungicides, herbicides, plant growth regulators or fertilizers, as the case requires. Now, typical formulations of the agricultural/horticultural fungicides of the present invention will be described with reference to Formulation Examples. Hereinafter, “%” means “% by weight”.

FORMULATION EXAMPLE 1 Dust

b 2% of Compound (I-45), 5% of diatomaceous earth and 93% of clay were uniformly mixed and pulverized to give a dust.

FORMULATION EXAMPLE 2 Wettable Powder

50% of Compound (I-170), 45% of diatomaceous earth, 2% of sodium dinaphthylmethanedisulfonate and 3% of sodium lignin sulfonate were uniformly mixed and pulverized to give a wettable powder.

FORMULATION EXAMPLE 3 Emulsifiable Concentrate

30% of Compound (I-309), 20% of cyclohexanone, 11% of polyoxyethylene alkyl aryl ether, 4% of calcium alkylbenzenesulfonate and 35% of methylnaphthalene were uniformly dissolved to give an emulsifiable concentrate.

FORMULATION EXAMPLE 4 Granule

5% of Compound (I-121), 2% of the sodium salt of the lauryl alcohol sulfuric ester, 5% of sodium lignin sulfonate, 2% of carboxymethyl cellulose and 86% of clay were uniformly mixed and pulverized. The resulting mixture was kneaded with 20% of water, granulated to 14 to 32 mesh by means of an extrusion granulator and dried to give a granule.

Now, the effects of the agricultural/horticultural fungicides of the present invention will be described with reference to specific Test Example.

TEST EXAMPLE 1 Test for Preventive Effect on Wheat Powdery Mildew

9 Wheat seeds (variety: Norin-61-go) were sown in each 9 cm×9 cm polyvinyl chloride pot, grown in a greenhouse for 8 days, then treated with 10 ml per pot of aqueous solutions of wettable powders prepared in accordance with Formulation Example 2, at a concentration of 500 ppm in terms of the active ingredients and dried in the air. Then, the seedlings were inoculated with Erysiphe graminis spores by sprinkle over the plant and placed in a greenhouse of from 20 to 25° C. 10 days after the inoculation, the total diseases area of the first leaves in each pot was observed and evaluated on the basis of the standards shown in Table 67. The results are shown in Tables 68 and 69.

TABLE 67 Evaluation A No diseased area B Diseased area of less than 25% C Diseased area of at least 25% but less than 50% D Diseased area of at least 50%

TABLE 68 Biological Compound effective- No. ness I-1 A I-2 A I-3 A I-6 B I-7 A I-10 B I-22 A I-23 A I-25 A I-26 A I-27 B I-29 B I-30 B I-35 B I-38 B I-40 B I-41 A I-45 A I-66 A I-82 A I-83 B I-84 A I-85 A I-87 A I-88 B I-91 B I-111 B I-112 B I-113 B I-114 B I-116 B I-122 B I-130 A I-131 A I-132 A I-133 A I-134 A I-135 A I-136 B I-141 A I-175 A I-176 A I-181 B I-183 B I-184 A I-185 A I-186 A I-188 A I-189 A I-192 B I-195 B I-199 B I-200 A I-201 A I-202 B I-203 B I-204 A I-208 B I-209 B I-212 B I-214 A I-215 A I-216 A I-217 A I-218 A I-219 A I-220 B I-221 B I-222 B I-225 A I-226 A I-229 A I-232 B I-234 A I-235 A I-239 A I-242 A I-250 B I-251 A I-255 A I-256 A I-258 A I-259 A I-260 A I-261 B I-263 A I-271 A I-272 A I-277 B I-279 A I-295 A I-296 A I-298 A I-299 A I-300 A I-301 A I-307 A I-309 A I-310 A I-311 A I-312 A I-313 A I-314 A I-315 B I-316 B I-318 A I-321 A I-327 A I-332 B I-333 A I-334 A I-335 A I-336 A I-346 A I-358 A I-359 A I-360 B I-362 A I-364 A I-366 A I-368 B I-369 B I-375 A I-376 B I-377 A I-378 A I-379 A I-380 A I-381 A I-388 A I-389 B I-394 A I-400 A I-404 B I-405 A I-406 A I-423 A I-424 A I-438 A I-457 B I-458 A I-461 A I-462 B I-465 B

TABLE 69 Biological Compound effective- No. ness I-479 A I-480 A I-482 A I-483 A I-486 A I-490 A I-498 A I-499 A I-501 A I-502 A I-503 A I-507 A I-508 B I-510 A I-511 A I-514 A I-515 A I-516 A I-530 A I-531 A I-534 A I-543 A I-544 A I-545 A I-546 A I-550 A I-573 B I-580 A I-592 A I-595 B I-601 A I-667 B I-669 B I-670 B I-671 B I-672 B I-675 B I-682 A I-683 A I-690 A I-692 B I-693 A I-694 B I-695 A I-704 B I-705 A I-726 B I-731 B I-752 A I-758 A I-762 A I-767 B I-768 A I-769 A I-771 A I-772 A I-775 A I-804 A I-805 B I-806 B I-809 B I-818 B I-831 B I-839 A I-840 B I-872 B I-883 A I-885 B I-894 B I-895 B I-903 B I-904 B I-915 A I-958 B I-959 A I-960 A I-962 A I-964 B I-965 A I-967 A I-999 A I-1004 A I-1019 A I-1022 A I-1043 A I-1046 A I-1048 A I-1058 A I-1059 A I-1064 B I-1071 A I-1079 B I-1082 B I-1085 A I-1086 B I-1087 A I-1088 A I-1090 B I-1093 A I-1094 A I-1095 A I-1096 A I-1098 A I-1103 B I-1104 B I-1106 B I-1123 B I-1147 B

The agricultural/horticultural fungicides of the present invention have a broad disease control spectrum, and have an excellent effect particularly on wheat powdery mildew. Further, they have high controlling effects on cucumber downy mildew, apple scab, rice blast, cucumber gray mold, rice sheath blight and wheat brown leaf rust, and are excellent in residual effectiveness and rain-fastness without damaging crops, and thus they are useful as agricultural/horticultural fungicides. 

1. A pyrimidinylbenzimidazole compound represented by formula [I]:

{wherein A is CR³, each of R¹ and R² which are independent of each other, is a hydrogen atom, a halogen atom, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₃-C₆) cycloalkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₃-C₆) cycloalkoxy group, a (C₁-C₄) haloalkoxy group, a cyano (C₁-C₄) alkyloxy group, a (C₁-C₄) alkoxy (C₁-C₄) alkyloxy group, a (C₃-C₆) cycloalkyl (C₁-C₄) alkoxy group, a benzyloxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₆) alkylthio group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a phenoxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₄) alkylcarbonyl group, a formyl group, a phenyl group, a di(C₁-C₄) alkylamino group, a cyano group or a (C₁-C₆) alkylsulfonyl group, R³ is a hydrogen atom, a (C₁-C₆) alkyl group, a (C₁-C₆) alkoxy group or a halogen atom, X is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₃-C₆) cycloalkyl group, a benzyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₁-C₆) alkylthio group, a (C₁-C₆) alkylsulfonyl group, a phenoxy group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₄) haloalkoxy group, a (C₁-C₄) alkylcarbonyl group, a (C₁-C₄) alkoxycarbonyl group, an amino group, a mono(C₁-C₄) alkylamino group, a di(C₁-C₄) alkylamino group, an anilino group or a phenyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], Y is a halogen atom, a nitro group, a cyano group, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₁-C₄) haloalkoxy group, a (C₁-C₆) alkylthio group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₄) alkylcarbonyl group, a (C₁-C₄) alkoxycarbonyl group, a benzoyl group, an amino group, a mono(C₁-C₄) alkylamino group, a di(C₁-C₄) alkylamino group, a phenyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group] or a phenoxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], and n is 0 or an integer of from 1 to 3}.
 2. An anilinopyrimidine compound represented by the formula [XVII]:

{wherein each of R¹ and R² which are independent of each other, is a hydrogen atom, a halogen atom, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynly group, a (C₃-C₆) cycloalkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₃-C₆) cycloalkoxy group, a (C₁-C₄) haloalkoxy group, a cyano (C₁-C₄) alkyloxy group, a (C₁-C₄) alkoxy (C₁-C₄) alkyloxy group, a (C₃-C₆) cycloalkyl (C₁-C₄) alkoxy group, a benzyloxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₆) alkylthio group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a phenoxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₄) alkylcarbonyl group, a formyl group, a phenyl group, a di(C₁-C₄) alkylamino group, a cyano group or a (C₁-C₆) alkylsulfonyl group, R³ is a hydrogen atom, a (C₁-C₆) alkyl group, a (C₁-C₆) alkoxy group or a halogen atom, X is a hydrogen atom, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₃-C₆) cycloalkyl group a benzyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₄) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₁-C₆) alkylthio group, a (C₁-C₆) alkylsulfonyl group, a phenoxy group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₄) haloalkoxy group, a (C₁-C₄) alkylcarbonyl group, a (C₁-C₄) alkoxycarbonyl group, an amino group, a mono (C₁-C₄) alkylamino group, a di(C₁-C₄) alkylamino group, an anilino group or a phenyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], Y is a halogen atom, a nitro group, a cyano group, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₁-C₄) haloalkoxy group, a (C₁-C₆) alkylthio group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a (C₁-C₄) haloalkoxyl group, a (C₁-C₄) alkylcarbonyl group, a (C₁-C₄) alkoxycarbonyl group, a benzoyl group, an amino group, a mono (C₁-C₄) alkylamino group, a di(C₁-C₄) alkylamino group, a phenyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group] or a phenoxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], and n is 0 or an integer of from 1 to 3}.
 3. An agricultural/horticultural fungicidal composition containing the pyrimidinylbenzimidazole compound as defined in claim 1, as the active ingredient and an agriculturally/horticulturally acceptable inert component.
 4. The pyrimidinylbenzimidazole compound according to claim 1, wherein each of R¹ and R² which are independent of each other, is a hydrogen atom, a halogen atom, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₃-C₆) cycloalkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₃-C₆) cycloalkoxy group, a (C₁-C₄) haloalkoxy group, a cyano (C₁-C₄) alkyloxy group, a (C₁-C₄) alkoxy (C₁-C₄) alkyloxy group, a (C₃-C₆) cycloalkyl (C₁-C₄) alkoxy group, a benzyloxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₆) alkylthio group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a (C₁-C₄) alkylcarbonyl group, a formyl group, a phenyl group, a cyano group or a (C₁-C₆) alkylsulfonyl group, R³ is a hydrogen atom, a (C₁-C₆) alkyl group, a (C₁-C₆) alkoxy group or a halogen atom, X is a hydrogen atom, a halogen atom, a nitro group, a (C₁-C₆) alkyl group, a (C₂-C₆) alkynyl group, a (C₃-C₆) cycloalkyl group, a benzyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₁-C₆) alkylthio group, a (C₁-C₆) alkylsulfonyl group, a phenoxy group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₄) haloalkoxy group, a (C₁-C₄) alkylcarbonyl group, a (C₁-C₄) alkoxycarbonyl group, an amino group, a mono (C₁-C₄) alkylamino group, a di(C₁-C₄) alkylamino group, an anilino group or a phenyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], Y is a halogen atom, a nitro group, a cyano group, a (C₁-C₆) alkyl group, a (C₂-C₆) alkenyl group, a (C₂-C₆) alkynyl group, a (C₁-C₆) alkoxy group, a (C₂-C₆) alkenyloxy group, a (C₂-C₆) alkynyloxy group, a (C₁-C₄) haloalkoxy group, a (C₁-C₆) alkylthio group, a (C₁-C₄) alkoxy (C₁-C₄) alkyl group, a (C₁-C₄) haloalkyl group, a (C₁-C₄) alkylcarbonyl group, a (C₁-C₄) alkoxycarbonyl group, a benzoyl group, an amino group, a mono (C₁-C₄) alkylamino group, a di(C₁-C₄) alkylamino group, a phenyl group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group] or a phenoxy group [said group may be substituted by a halogen atom, a (C₁-C₄) alkyl group or a (C₁-C₄) alkoxy group], and n is 0 or an integer of from 1 to
 3. 5. An agricultural/horticultural fungicidal composition containing the pyrimidinylbenzimidazole compound as defined in claim 4, as the active ingredient and an agriculturally/horticulturally acceptable inert component. 